Antibodies to Pf155/RESA and circumsporozoite protein of Plasmodium falciparum in paired maternal-cord sera from Nigeria

Parasite Immunology
E A AchidiK Berzins

Abstract

Paired maternal-cord serum samples were analysed for antibodies to the Pf155/RESA and circumsporozoite protein (CSP) antigens of Plasmodium falciparum. Malaria parasites were found in 2.6% (3/117) of cord blood and 22.4% (26/116) of maternal samples. Immunofluorescence assays detected P. falciparum-specific IgG antibodies in all paired samples while P. falciparum-specific IgM was detected in 5.8% (7/121) of cord samples. The positivity rates for antibodies to Pf155/RESA and (NANP)6 but not (EENV)6, a C-terminal repeat sequence of Pf155/RESA, were significantly higher in maternal as compared with cord samples. Seropositivity rates to Pf155/RESA and (EENV)6 were not related to maternal parity group while positivity rates to the (NANP)6 peptide were higher in primiparae and multiparae of > or = 4 parity. These data confirm the transplacental transfer of P. falciparum-specific antibodies and the higher incidence of malaria parasitaemia in primiparae. The presence of P. falciparum-specific IgM in some cord samples suggests intrauterine sensitization of the foetus to malarial antigens.

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Citations

Apr 15, 2004·Placenta·B J BrabinJ Ordi
Aug 8, 2008·The Journal of Infectious Diseases·Ayôla A AdegnikaMaria Yazdanbakhsh
Sep 1, 1969·Experimental Cell Research·M Raftell, P Perlmann
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Nov 4, 2006·Molecular and Biochemical Parasitology·Kelly BroenAdrian J F Luty
Sep 28, 2017·PloS One·Samuel Tassi YungaDiane W Taylor

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