PMID: 5917082Sep 30, 1966

Antibodies to photoproducts of deoxyribonucleic acids irradiated with ultraviolet light

L LevineH Van Vunakis


A rabbit immunized with complexes of methylated bovine serum albumin and ultraviolet-irradiated DNA from calf thymus produced antibodies directed toward the photoproducts in the DNA. Serologic activity appeared after irradiation of DNA at 270 mmicro and decreased upon irradiation at 235 mmicro. The antigenic determinants of the ultraviolet-treated DNA appear to be photoproducts associated primarily with thymine, as measured by direct dependence of serologic activity on the adenine-thymine content of the DNA, and by inhibition of the Serlolgic reaction by the irradiated di-,tri-,and tetra-(thymidine-5'-phosphate nucleotides.


Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·R Müller, M F Rajewsky
Jul 30, 1979·Archives of Dermatological Research·R H CormaneA H Siddiqui
Oct 1, 1988·The Histochemical Journal·T KojiP K Nakane
Feb 22, 2012·Analytical and Bioanalytical Chemistry·Zahra J Shire, Glen R Loppnow
Jul 1, 1976·Immunochemistry·V K PodgorodnichenkoA M Poverenny
May 10, 1979·Journal of Immunological Methods·E V Barnett
Jan 1, 1981·Journal of Immunological Methods·P T Strickland, J M Boyle
Jun 24, 1992·Journal of Immunological Methods·P K Nakane
Jun 12, 2003·Journal of Immunological Methods·Aikaterini KarakoulaM S Cooke
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yukihiro EsakaMasashi Goto
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·E M Tan, R B Stoughton
Aug 1, 1977·The British Journal of Dermatology·P Davis
Aug 1, 1978·The British Journal of Dermatology·P Davis, J S Percy
Oct 17, 1968·European Journal of Biochemistry·R HernandezM Just
Sep 1, 1977·Photochemistry and Photobiology·J J CornelisM Errera
Nov 1, 1979·Photochemistry and Photobiology·A Wakizaka, E Okuhara
Oct 1, 1984·Photochemistry and Photobiology·A A WaniS M D'Ambrosio
Dec 1, 1984·Photochemistry and Photobiology·D L Mitchell, J M Clarkson
Apr 1, 1989·Photochemistry and Photobiology·T MoriJ E Trosko
Dec 17, 2009·Photochemistry and Photobiology·D L Mitchell, Becky Brooks
Sep 1, 1970·Annals of the Rheumatic Diseases·J H Veen, C J Lucas
Feb 1, 1972·The Journal of Clinical Investigation·P G Natali, E M Tan
Jan 1, 1981·Radiation and Environmental Biophysics·H WallerJ Kiefer
Aug 27, 1981·Biochimica Et Biophysica Acta·D L Mitchell, J M Clarkson
Jan 1, 1978·Progress in Histochemistry and Cytochemistry·M FukudaS Fujita
Jan 1, 1985·Environmental Mutagenesis·P T Strickland
Aug 1, 1969·Journal of the American Geriatrics Society·J G Makari
Jun 24, 1998·Cell Biochemistry and Function·K KayashimaP K Nakane
May 25, 1971·Biochemistry·L LevineR C Gallo
Dec 1, 1986·Jinrui idengaku zasshi. The Japanese journal of human genetics·A OhtaM Yamaguchi
Jul 1, 1988·Photochemistry and Photobiology·R G Phillips, K Kalthoff

Related Concepts

Antibody Formation
Antigen-Antibody Reactions
DNA, Bacterial
Effects of Radiation
Serum Albumin, Bovine
Black Light, Ultraviolet

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