Antibodies to ribosomal P proteins: a potential serologic marker for lupus membranous glomerulonephritis

Arthritis and Rheumatism
Ana Patrícia do NascimentoE Bonfa

Abstract

To evaluate the relevance of antibodies to ribosomal P proteins (anti-P antibodies) in discriminating histopathologic patterns of lupus nephritis. The study group comprised 81 consecutive patients with systemic lupus erythematosus who underwent renal biopsy and for whom frozen serum was available at the time of biopsy. All biopsy specimens were reviewed in a blinded manner, according to the 2004 criteria of the International Society of Nephrology and the Renal Pathology Society. Anti-P antibodies were detected by enzyme-linked immunosorbent assay (ELISA)/immunoblot analysis, and anti-double-stranded DNA (anti-dsDNA) was detected by indirect immunofluorescence/ELISA. Anti-P antibodies were detected in 18 patients (22%). The demographic and clinical features of patients with and those without anti-P antibodies were similar. Remarkably, analyses of biopsy specimens revealed that the frequency of anti-P antibodies in patients with class V lupus nephritis was higher than the frequency among patients with other classes of renal disease (72% versus 28%; P = 0.005). Accordingly, anti-P antibody-positive patients had a higher mean (+/-SD) proteinuria level compared with anti-P antibody-negative patients (6.4 +/- 4.8 versus 4.7 +/- 3.9 g...Continue Reading

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Citations

Apr 12, 2007·Clinical Reviews in Allergy & Immunology·Emese Kiss, Yehuda Shoenfeld
Jun 16, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiao-wei YangMing-hui Zhao
Sep 29, 2009·Rheumatology International·Jozélio Freire de CarvalhoEloísa Bonfá
Mar 26, 2014·Journal of Autoimmunity·Dana Ben-Ami ShorYehuda Shoenfeld
Jun 8, 2011·Clinical and Experimental Nephrology·Shunsei Hirohata
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Oct 9, 2014·Expert Review of Clinical Immunology·Sandra Gofinet PasotoEloisa Bonfa
Jul 1, 2007·Expert Review of Clinical Immunology·Paula AlbaMunther A Khamashta
Dec 20, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Iva GunnarssonJohan Rönnelid
Sep 14, 2010·Autoimmunity Reviews·Patrícia Andrade de MacedoEloísa Bonfá
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Apr 11, 2017·Lupus·V T VianaK B Elkon
Jan 14, 2020·Autoimmunity Reviews·May Y ChoiMarvin J Fritzler

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