Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

ELife
Per Johan Klasse, John P Moore

Abstract

We review aspects of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from recovered patients, monoclonal antibodies against the viral S-protein, and soluble forms of the receptor for the virus, angiotensin converting enzyme 2. The development of vaccines against SARS-CoV-2, an essential public health tool, will also be informed by an understanding of the antibody response in infected patients. Although virus-neutralizing antibodies are likely to protect, antibodies could potentially trigger immunopathogenic events in SARS-CoV-2-infected patients or enhance infection. An awareness of these possibilities may benefit clinicians and the developers of antibody-based therapies and vaccines.

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Citations

Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Oct 31, 2020·Wiener klinische Wochenschrift·Franz X Heinz, Karin Stiasny
Feb 2, 2021·Cell Reports Medicine·Kazuhito HonjoRandall S Davis
Feb 2, 2021·The Journal of Biological Chemistry·Youjia GuoKensaku Murano
Feb 27, 2021·PLoS Pathogens·Kuan-Ying A HuangAlain R Townsend
Mar 25, 2021·Journal of Integrative Bioinformatics·Anusha UttarilliAbhishek Kumar
Oct 17, 2020·Human Vaccines & Immunotherapeutics·Rabeea SiddiqueSuliman Khan
Apr 21, 2021·Nature Reviews. Immunology·Peter C TaylorRobert L Gottlieb
May 8, 2021·The Journal of General Virology·Joseph W GoldenJay W Hooper
Jun 25, 2021·PLoS Pathogens·Min ZhaoUNKNOWN Yale IMPACT Research Team
Jun 21, 2021·Computers in Biology and Medicine·Jiao ChenPeng Cao
Jun 18, 2021·Frontiers in Molecular Biosciences·Arnaud John Kombe KombeTengchuan Jin
Jul 30, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M HelmR Freitag
May 9, 2021·Journal of Virology·George W CarnellJohn A G Briggs

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Methods Mentioned

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