Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

The New England Journal of Medicine
D VerganiR Williams

Abstract

Circulating antibodies reacting specifically with the cell membrane of hepatocytes isolated from halothane-anesthetized rabbits were detected in nine of 11 patients with fulminant hepatic failure after helothane-induced anesthesia. The immunoglobulin deposition, as revealed by immunofluorescence, showed a granular pattern on the hepatocyte surface membrane. Preincubation of halothane-pretreated, but not of control, hepatocytes with serum containing this antibody rendered them susceptible to cytotoxic effects of normal lymphocytes in vitro. Control studies using serum from subjects repeatedly exposed to halothane without the development of liver damage, and from patients with viral and toxic liver injury have confirmed the specificity of these findings to serve halothane-associated liver injury. These results provide further evidence of an immunologic component in this condition.

References

Nov 15, 1977·Biochemical Pharmacology·B R Brown, I G Sipes
Jul 1, 1979·British Journal of Anaesthesia·B Wardley-Smith, M J Halsey
Feb 1, 1979·Anaesthesia and Intensive Care·M J CousinsR Whitehead
Jan 1, 1979·Anesthesiology·J H SharpE N Cohen
Dec 1, 1976·Anesthesiology·I G Sipes, B R Brown
May 15, 1976·British Medical Journal·B WaltonA J Appleyard
Aug 24, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·H UehlekeS Tabarelli-Poplawski
Jul 3, 1971·British Medical Journal·W W MushinE V Jones

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Citations

Mar 1, 1983·Canadian Anaesthetists' Society Journal·L Strunin, J M Davies
May 1, 1985·Canadian Anaesthetists' Society Journal·M J CousinsP D Hall
May 14, 1999·European Journal of Drug Metabolism and Pharmacokinetics·P M DansetteD Mansuy
Aug 10, 2010·European Journal of Clinical Pharmacology·Hugh G LavertyB Kevin Park
Nov 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A J HusseyG J Beckett
Oct 14, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·C M CooperD B Olivera
Dec 27, 1985·Journal of Immunological Methods·J G KennaR S Williams
Jan 1, 1988·Pharmacology & Therapeutics·P H Beaune, F P Guengerich
Jan 1, 1993·Pharmacology & Therapeutics·J GutJ Huwyler
Jan 1, 1987·International Journal of Immunopharmacology·J M NeubergerR Williams
Jan 1, 1991·International Journal of Immunopharmacology·A P BrownA J Gandolfi
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L SiproudhisA Guillouzo
Jul 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F N van PeltJ G Kenna
Jun 1, 1993·European Journal of Pharmacology·E HeijinkI N White
Jul 1, 1987·Baillière's Clinical Gastroenterology·J Neuberger, R Williams
Apr 1, 1988·Baillière's Clinical Gastroenterology·D Pessayre, D Larrey
Oct 10, 1981·Lancet·R Wilbur, F A Kulik
Jan 1, 1997·Journal of Hepatology·P H Beaune, S Lecoeur
Apr 11, 1997·Toxicology·J P Uetrecht
Oct 1, 1993·Transfusion Medicine Reviews·D J Christie
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shufeng Zhou
Jun 7, 2011·Chemical Research in Toxicology·J S BoermaJ N M Commandeur
Jun 3, 2005·Nature Reviews. Drug Discovery·Neil Kaplowitz
Aug 18, 1983·The New England Journal of Medicine·W W DinsmoreM E Callender
Nov 21, 1985·The New England Journal of Medicine·B R Brown
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W HarrisM W Anders
May 9, 1987·British Medical Journal·J G KennaR Williams
Jul 1, 1982·Gut·R MeliconiR Williams
Apr 1, 1989·Gut·J Neuberger, R Williams
Sep 1, 1991·Gut·J M Tredger, M Davis
Sep 1, 1991·Gut·A L EddlestonB D Reed
Sep 1, 1991·Gut·R D HughesA E Gimson
Nov 1, 1983·Journal of Clinical Pathology·R S AnthonyR N MacSween
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·N R Pumford, N C Halmes
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·J R Gillette
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·B Kevin ParkDominic P Williams
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·Jack Uetrecht

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