Antibodies to thromboplastin in systemic lupus erythematosus: isotype distribution and clinical significance in a series of 92 patients

Thrombosis Research
J FontM Ingelmo

Abstract

We determined the prevalence and relationship with clinical manifestations of antibodies to thromboplastin (aTP) in 92 patients with systemic lupus erythematosus (SLE). Thirty-two (35%) patients had aTP: 13 (14%) were positive for IgG aTP, 13 (14%) for IgM aTP, and 6 (7%) for both. Patients with aTP had an increased incidence of thrombosis (p = 0.01), thrombocytopenia (p < 0.001), hemolytic anemia (p < 0.001), and fetal losses (p = 0.03). When the IgG and IgM aTP isotypes were analysed separately, the IgG aTP were found to be associated with thrombosis (p < 0.001), thrombocytopenia (p < 0.001), and fetal losses (p = 0.02). The IgM aTP were associated with hemolytic anemia (p < 0.001). A correlation was found between the titers of aTP and those of anticardiolipin antibodies, in both IgG (p < 0.01, r = 0.6) and IgM (p < 0.01, r = 0.64) isotypes, and between the titers of IgG aTP and the diluted Russell's viper venom time used to detect the lupus anticoagulant (p < 0.001, r = 0.42). This test is a reliable, reproducible and sensitive assay for the detection of antiphospholipid antibodies, specially in those patients under anticoagulant therapy.

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Citations

Jun 30, 2009·Clinical Reviews in Allergy & Immunology·Miri Blank, Yehuda Shoenfeld
May 21, 1999·Thrombosis Research·E M JacobsenF Wisløff
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Sep 6, 2001·Rheumatic Diseases Clinics of North America·M J Cuadrado, G R Hughes
Jan 4, 2008·Journal of Autoimmunity·Yehuda ShoenfeldYaniv Sherer
Oct 26, 2016·Journal of Autoimmunity·Alba Velo-GarcíaDavid A Isenberg
Oct 16, 2004·Lupus·Y Shoenfeld, M Blank
Apr 11, 2015·Lupus Science & Medicine·Anum FayyazR Hal Scofield

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.