PMID: 9536843Apr 16, 1998Paper

Antibodies to varicella zoster virus in the cerebrospinal fluid of neonates with seizures

Archives of Disease in Childhood. Fetal and Neonatal Edition
Kirsi MustonenMarjaleena Koskiniemi

Abstract

Four neonates with convulsions had IgG antibodies in their cerebrospinal fluid (CSF) to varicella zoster virus (VZV). These antibodies were found in the sera of two of these patients after the age of 6 months. Antibodies to 16 different microbes were studied from the serum and CSF of 201 neonates with neurological problems. The presence of DNA specific to HSV-1, HSV-2, and VZV in the CSF was also investigated using the polymerase chain reaction (PCR). Antibodies to VZV were detected in the CSF of four neonates. Antibody indices suggested production of VZV specific antibodies in the central nervous system. These findings suggest that intrathecal production of antibodies to VZV can appear in neonates with neurological problems, which suggests that intrauterine VZV infection can be acquired without cutaneous symptoms in the mother.

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Citations

Sep 25, 2003·The Pediatric Infectious Disease Journal·Sarah N MattsonChristina D Chambers
Mar 29, 2003·Journal of Perinatal Medicine·Kirsi MustonenMarjaleena Koskiniemi
Mar 29, 2003·Journal of Perinatal Medicine·Kirsi MustonenMarjaleena Koskiniemi
Apr 28, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·K MustonenM Koskiniemi
Jul 13, 2007·Clinical and Vaccine Immunology : CVI·Marjaleena KoskiniemiVladimir N Loparev
Mar 23, 2006·Infection and Immunity·László Maródi

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