Antibodies to Zika virus, Campylobacter jejuni and gangliosides in Guillain-Barre syndrome: A prospective single-center study from southern India

Neurology India
Dipti BaskarK Vanathi

Abstract

The objective of this article was to study the presence of antibodies against Zika virus (ZIKV), Campylobacter jejuni, and gangliosides in patients with Guillain-Barre syndrome (GBS). Ninety consecutive patients (age more than 12 years) with GBS admitted to a tertiary care center in southern India were included in this study. Data on clinical manifestations, nerve conduction studies, and response to therapy were collected. The following tests were done in stored serum samples - anti-ZIKV (IgM) antibodies, anti-C. jejuni (IgG) antibodies, and anti-ganglioside antibodies (IgG). Those samples which were positive to anti-Zika antibodies were tested for conventional polymerase chain reaction for ZIKV and IgM antibodies against dengue, and Japanese encephalitis virus. Of the 90 patients, 3 died and 8 had persistent weakness. Acute inflammatory demyelinating polyradiculoneuropathy was the most common type of GBS (56.7%). Anti-ganglioside antibodies were present in 62.2% patients with GT1b being the most common. Anti-C. jejuni antibodies were present in 46.6%. Anti-Zika antibodies (IgM) were present in 14 patients (15.5%). Four of these patients also had anti-dengue antibody (IgM) positivity. This is one of the largest studies on GBS f...Continue Reading

Citations

Feb 13, 2019·Journal of Travel Medicine·Davidson H Hamer, Lin H Chen
Sep 19, 2019·PLoS Neglected Tropical Diseases·Juan Rivera-CorreaAna Rodriguez
Jul 18, 2018·PLoS Neglected Tropical Diseases·Elodie CalvezMyrielle Dupont-Rouzeyrol
Oct 24, 2019·QJM : Monthly Journal of the Association of Physicians·Nitin GuptaAshutosh Biswas
Sep 21, 2018·Neurology India·Ravindra Kumar GargImran Rizvi
Mar 11, 2020·Cellular & Molecular Immunology·Gianni CutilloSeppo Meri
May 28, 2021·Frontiers in Immunology·Shahrzad ShorakaAmir Ghaemi
Jul 14, 2021·Journal of the Peripheral Nervous System : JPNS·Debprasad DuttaVasanthapuram Ravi

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