PMID: 2102772Jan 1, 1990

Antibody activity against lipopolysaccharides, lipid A and proteins from Enterobacteriaceae in patients with chronic inflammatory liver diseases

R StemerowiczU Hopf


These studies are concerned with detection of circulating antibodies against various defined enterobacterial antigens in patients with chronic inflammatory liver diseases such as chronic hepatitis type B (n = 46), chronic active hepatitis (CAH) of autoimmune type (n = 10), alcoholic cirrhosis (n = 24) and primary biliary cirrhosis (PBC) (n = 24) as well as in healthy individuals (n = 39). Anti-LPS and anti-lipid A were determined by hemolytic and hemagglutination assay. Immunoblot technique was used to investigate the antibody activity against plasmid encoded proteins from Yersinia enterocolitica. Persistent titers of anti-LPS up to serum dilution 1:32.768 were found with hemolytic and hemagglutination assay in patients with alcoholic cirrhosis or PBC and in healthy control. In contrast nearly 50% of patients with chronic hepatitis B had no hemolytic antibodies against the two LPS E. coli serotypes at the time of liver biopsy. Anti-lipid A was detectable in 58% of patients with alcoholic cirrhosis but in low titers in less than 10% in the other groups (p less than 0.001). Alcoholic cirrhosis was also associated with a high frequency of IgG and IgA antibodies against plasmid encoded proteins from Yersinia enterocolitica. The dat...Continue Reading


Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Nov 1, 1975·Gut·A E SimjeeS Sherlock
Mar 11, 1976·The New England Journal of Medicine·U HopfW Arnold
Jan 1, 1990·Clinical and Experimental Immunology·U HopfP A Berg
Jan 25, 1986·Lancet·J P NolanN C Gagliardi
Aug 14, 1971·Lancet·R L ProtellW H Summerskill
Jan 8, 1972·Lancet·D R TrigerR Wright
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
May 1, 1968·The Journal of Clinical Investigation·I R Cohen, L C Norins
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·N R DiLuzio, C G Crafton
Mar 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C ThomasS Sherlock
Apr 1, 1983·The British Journal of Venereal Diseases·B R Møller
Oct 1, 1982·Epilepsia·R Palm, G Hallmans
Jul 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·N CREMER, D W WATSON
Jan 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·H E NOYESG J BLAHUTA


Jan 1, 1991·Immunologic Research·U Hopf, R Stemerowicz
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·A C DoudsT A Poulton
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Katherine L LeicesterBruce R Bacon
Dec 3, 2014·Gastroenterology·Gyongyi Szabo
Feb 5, 2019·Journal of Clinical Laboratory Analysis·Jing QiuChen Dong

Related Concepts

Antibodies, Bacterial
Chronic Alcoholic Hepatitis
Chronic Persistent Hepatitis
Lipid A
Fibrosis, Liver
Liver Cirrhosis, Alcoholic

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.