PMID: 2102772Jan 1, 1990

Antibody activity against lipopolysaccharides, lipid A and proteins from Enterobacteriaceae in patients with chronic inflammatory liver diseases

Autoimmunity
R StemerowiczU Hopf

Abstract

These studies are concerned with detection of circulating antibodies against various defined enterobacterial antigens in patients with chronic inflammatory liver diseases such as chronic hepatitis type B (n = 46), chronic active hepatitis (CAH) of autoimmune type (n = 10), alcoholic cirrhosis (n = 24) and primary biliary cirrhosis (PBC) (n = 24) as well as in healthy individuals (n = 39). Anti-LPS and anti-lipid A were determined by hemolytic and hemagglutination assay. Immunoblot technique was used to investigate the antibody activity against plasmid encoded proteins from Yersinia enterocolitica. Persistent titers of anti-LPS up to serum dilution 1:32.768 were found with hemolytic and hemagglutination assay in patients with alcoholic cirrhosis or PBC and in healthy control. In contrast nearly 50% of patients with chronic hepatitis B had no hemolytic antibodies against the two LPS E. coli serotypes at the time of liver biopsy. Anti-lipid A was detectable in 58% of patients with alcoholic cirrhosis but in low titers in less than 10% in the other groups (p less than 0.001). Alcoholic cirrhosis was also associated with a high frequency of IgG and IgA antibodies against plasmid encoded proteins from Yersinia enterocolitica. The dat...Continue Reading

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Citations

Jan 1, 1991·Immunologic Research·U Hopf, R Stemerowicz
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·A C DoudsT A Poulton
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Katherine L LeicesterBruce R Bacon
Dec 3, 2014·Gastroenterology·Gyongyi Szabo
Feb 5, 2019·Journal of Clinical Laboratory Analysis·Jing QiuChen Dong

Related Concepts

Antibodies, Bacterial
Autoantibodies
Chronic Alcoholic Hepatitis
Chronic Persistent Hepatitis
IgA2
Polyglobin
Lipid A
Lipopolysaccharides
Fibrosis, Liver
Liver Cirrhosis, Alcoholic

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