Antibody against human immunodeficiency virus type 1 (HIV-1) Tat protein may have influenced the progression of AIDS in HIV-1-infected hemophiliac patients.

Clinical and Diagnostic Laboratory Immunology
M C ReM La Placa

Abstract

Retrospective analysis of serum samples from a group of hemophiliac patients who became infected with human immunodeficiency virus type 1 (HIV-1) between 1984 and 1985 has shown that, at variance with other HIV-1-infected patients, at the onset, or at least at a very early phase of HIV-1 infection, they constantly have elevated levels of antibodies against HIV-1-transactivating Tat protein and an absent or barely detectable p24 antigenemia. Anti-Tat antibodies in initial serum samples from hemophiliac patients were probably the consequence of the passive administration of immunoglobulins present in low- or intermediate-purity clotting factor concentrates prepared from HIV-1-infected blood. Furthermore, the analysis of serial serum samples obtained during the course of the disease, in which passively acquired anti-Tat antibodies were substituted by actively produced antibodies, demonstrated an inverse relationship between anti-Tat antibody and p24 anti-genemia levels throughout the observation period. These data seem to suggest that anti-Tat antibody may have some influence on the course of HIV-1 infection.

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Citations

Mar 28, 2008·AIDS Research and Human Retroviruses·D SenkaaliP Kaleebu
Jul 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·S M AgwaleD M Hone
Jul 10, 2013·AIDS·Selina PoonR Holland Cheng
Oct 9, 2009·International Reviews of Immunology·Antonella CaputoBarbara Ensoli
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Anna Maria Gorska, Eliseo A Eugenin
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·S S CohenD I Cohen
Oct 27, 1999·Biochemical Pharmacology·K Watson, R J Edwards
Mar 13, 1999·Biochemical Pharmacology·K WatsonR J Edwards

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