PMID: 3751232Jan 1, 1986Paper

Antibody and cellular immune responses to microfilarial antigens in ferrets experimentally infected with Brugia malayi

Zeitschrift Für Parasitenkunde
J P ThompsonC A Crandall

Abstract

Eleven of 15 ferrets experimentally infected with Brugia malayi became amicrofilaremic after a brief patency; only four ferrets remained patent after 6 months of infection and two of these ferrets developed a high, persistent microfilaremia. Blastogenic responses of peripheral blood lymphocytes to antigens of microfilariae (mf), assayed in vitro, demonstrated an antigen sensitivity at prepatent, patent and postpatent periods of infection. Lymphocytes from ferrets with high microfilaremia had elevated background responses in culture which were directly correlated with the number of circulating mf. This background response was attributed to antigenic stimulation by mf present in the lymphocyte cultures; addition of mf to cultures of lymphocytes from postpatent ferrets induced responses equivalent to those observed in microfilaremic ferrets. Lymphocyte responses to the mitogen, concanavalin A, did not differ significantly among microfilaremic, amicrofilaremic and uninfected ferrets. Antibody in IgG to antigens of mf measured by ELISA and by immunoblots from SDS-PAGE showed similar patterns of response in ferrets which became amicrofilaremic and in the few ferrets which remained microfilaremic. prausnitz-Kustner tests demonstrated ...Continue Reading

References

May 18, 1978·The New England Journal of Medicine·F A Neva, E A Ottesen
Mar 1, 1976·The American Journal of Tropical Medicine and Hygiene·D B Benjamin, E J Soulsby
Mar 1, 1985·The American Journal of Tropical Medicine and Hygiene·W K TamashiroA L Scott
Dec 1, 1971·Experimental Parasitology·C A Crandall, R B Crandall
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·E A Ottesen
Apr 10, 1980·The New England Journal of Medicine·W F PiessensD T Dennis
Jul 1, 1982·The American Journal of Tropical Medicine and Hygiene·R B CrandallJ W McCall

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