Antibody and IFN-gamma responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus

Veterinary Immunology and Immunopathology
R PaillotJ M Daly

Abstract

In horses, equine influenza virus (EIV) is a leading cause of respiratory disease. Conventional inactivated vaccines induce a short-lived immune response. By comparison, natural infection confers a long-term immunity to re-infection. An aim of new equine influenza vaccines is to more closely mimic natural infection in order to achieve a better quality of immunity. A new live recombinant vaccine derived from the canarypox virus vector and expressing haemagglutinin genes of EIV (subtype H3N8) has been developed. Stimulation of the immune system was studied after immunisation with this canarypox-based vaccine and challenge infection by exposure to a nebulised aerosol of EIV. The humoral immune response was evaluated by measuring serum antibody levels using the single radial haemolysis (SRH) assay. The cellular immune response was assessed by the measurement of interferon gamma (IFN-gamma) synthesis in peripheral blood mononuclear cells (PBMC). Clinical signs of the disease (temperature, coughing, nasal discharge, dyspnoea, depression and anorexia) and virus excretion were monitored after challenge infection. Clinical signs and virus shedding were significantly reduced in vaccinates compared with unvaccinated controls. EIV-specific...Continue Reading

References

Feb 1, 1987·The Journal of Experimental Medicine·F GotchB Moss
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Moss
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·E Paoletti
Mar 11, 2004·Veterinary Immunology and Immunopathology·C C BreathnachD P Lunn

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Citations

Apr 9, 2015·Viruses·Lucas Sánchez-SampedroMariano Esteban
Dec 19, 2009·Veterinary Immunology and Immunopathology·Gisela SobollDavid P Lunn
Jun 23, 2010·Vaccine·Koert J StittelaarAlbert D M E Osterhaus
Jul 28, 2016·Human Vaccines & Immunotherapeutics·Rory D de Vries, Guus F Rimmelzwaan
Apr 14, 2016·Veterinary Microbiology·Rebecca KinsleyJanet M Daly
Oct 6, 2018·Vaccines·Mohamed DilaiOuafaa Fassi Fihri
Jul 28, 2016·NPJ Vaccines·Vanessa Guillaume-VasselinBranka Horvat
Jul 8, 2011·Australian Veterinary Journal·N R PerkinsI Links
Apr 16, 2011·Equine Veterinary Journal·D Elton, N Bryant
Jul 16, 2020·Vaccines·Johanna EntenfellnerAnn Cullinane
Apr 15, 2008·The Veterinary Record·Neil BryantMartin Jeggo
Jun 3, 2021·Animal Health Research Reviews·Luís DionísioAna I Faustino-Rocha
Aug 29, 2021·Viruses·Fatai S OladunniThomas M Chambers

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