Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients with ESKD, and vaccination is hoped to prevent infection. Between January 18 and February 24, 2021, 225 kidney transplant recipients (KTRs) and 45 patients on hemodialysis (HDPs) received two injections of mRNA BNT162b2 vaccine. The postvaccinal humoral and cellular response was explored in the first 45 KTRs and ten HDPs. After the second dose, eight HDPs (88.9%) and eight KTRs (17.8%) developed antispike SARS-CoV-2 antibodies (P<0.001). Median titers of antibodies in responders were 1052 AU/ml (IQR, 515-2689) in HDPs and 671 AU/ml (IQR, 172-1523) in KTRs (P=0.40). Nine HDPs (100%) and 26 KTRs (57.8%) showed a specific T cell response (P=0.06) after the second injection. In responders, median numbers of spike-reactive T cells were 305 SFCs per 106 CD3+ T cells (IQR, 95-947) in HDPs and 212 SFCs per 106 CD3+ T cells (IQR, 61-330) in KTRs (P=0.40). In KTRs, the immune response to BNT162b2 seemed influenced by the immunosuppressive regimen, particularly tacrolimus or belatacept. Immunization with BNT162b2 seems more efficient in HDPs, indicating that vaccination should be highly recommended in these patients awaitin...Continue Reading
References
Aug 13, 2010·Kidney International·Geertrude H StruijkFrederike J Bemelman
Aug 20, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Marta CrespoJulio Pascual
Dec 20, 2011·Vaccine·Paungpaga LertdumronglukChuencheevit Chotpitayasunondh
Mar 2, 2013·PloS One·Isabella EckerleThomas Junghanss
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Danziger-IsakovUNKNOWN AST Infectious Diseases Community of Practice
Jul 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marc LúciaOriol Bestard
Aug 2, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Pérez-RomeroUNKNOWN Influenza Vaccine in Solid Organ Transplant Recipient Study Group Spanish Network of Research in Infectious Diseases REIPI-G
Feb 13, 2016·Scientific Reports·Yu-Tzu ChangJunne-Ming Sung
Sep 29, 2017·Frontiers in Immunology·Nicolle H R LitjensMichiel G H Betjes
May 18, 2018·Current Opinion in Infectious Diseases·Cédric Hirzel, Deepali Kumar
Oct 6, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Karen M KruegerCybele Ghossein
Feb 8, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dominique BertrandDominique Guerrot
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Aug 28, 2020·Kidney International·Sophie CaillardUNKNOWN French SOT COVID Registry
Sep 27, 2020·Kidney International·Kitty J JagerZiad A Massy
Oct 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sophie CandonDominique Bertrand
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Nov 1, 2020·Journal of Clinical Medicine·Dominique BertrandJohan Noble
Nov 3, 2020·Kidney International·Olivier ThaunatUNKNOWN French nationwide Registry of Solid Organ Transplant Recipients with COVID-19
Nov 6, 2020·Transplantation·Yorg AzziEnver Akalin
Dec 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sophie CaillardUNKNOWN French SOT COVID Registry
Dec 16, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lara Danziger-IsakovMartina Sester
Mar 16, 2021·JAMA : the Journal of the American Medical Association·Brian J BoyarskyJacqueline M Garonzik-Wang
Mar 30, 2021·Kidney International·Ilies BenotmaneSophie Caillard
Citations
Jul 27, 2021·Néphrologie & thérapeutique·Hamza SakhiDany Anglicheau
Aug 15, 2021·EBioMedicine·Monika StrengertGeorg M N Behrens
Aug 28, 2021·Journal of Personalized Medicine·Cheng-Chieh YenShang-Jyh Hwang
Aug 29, 2021·EBioMedicine·Paul Martin, Candice Clarke
Aug 13, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amélie JacqMathieu Legendre
Sep 7, 2021·Frontiers in Medicine·Claudius SpeerLouise Benning
Aug 26, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nathalie ChavarotAnne Scemla
Sep 13, 2021·Nephrology·Joel SwaiShaojun Liu
Sep 11, 2021·Clinical Transplantation·Ayelet GrupperHelena Katchman
Jul 27, 2021·Transplantation·Arnaud DevresseNada Kanaan
Sep 23, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Marta CrespoUNKNOWN Mariscovid Research Group
Oct 5, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rezzan Eren SadioğluAydın Türkmen
Oct 29, 2021·JAMA Network Open·Jia-Jin ChenChih-Hsiang Chang
Aug 14, 2021·Transplantation·Johan NobleLionel Rostaing
Sep 23, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Marta KantauskaiteJohannes Stegbauer
Oct 26, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Dhakshayini TharmarajWilliam R Mulley
Oct 29, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Jesper M MagnussonMihai Oltean
Oct 1, 2021·Journal of the American Society of Nephrology : JASN·Jens Van PraetAn S De Vriese
Nov 16, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Benjamin E Hippen
Dec 4, 2021·Infectious Diseases and Therapy·Sarinya BoongirdJackrapong Bruminhent