PMID: 8995065Dec 1, 1996Paper

Antibody-antigen recognition: a canonical structure paradigm

Journal of Molecular Evolution
F Lara-OchoaM Conrad

Abstract

The antibodies of known three-dimensional structure exhibit a definite number of conformations (canonical structures) for five of six hypervariable loops. In the present study it was found that approximately 85% of the immunoglobulin sequences analyzed fall into a small number of canonical structure combinations, representing only 3% of the total possible. These structures were classified into six distinct groups, depending on the type of antigen with which they interact. Within each loop, the positions responsible for maintaining these canonical structures show a use frequency of amino acids that fits an inverse power law, whereas the use frequency of the amino acids responsible for the detailed antigenic specificity follows an exponential distribution. We propose an evolutionary interpretation that connects these data, using the fact that the inverse power law is generated by statistical processes of the type that yield a wealth curve and the fact that exponential distribution is generated by processes that are not biased by past history.

References

Sep 21, 1979·Journal of Theoretical Biology·M V Volkenstein
May 25, 1977·Journal of Molecular Biology·F C BernsteinM Tasumi
Oct 5, 1992·Journal of Molecular Biology·C ChothiaG Winter
Jan 1, 1990·Bio Systems·M Conrad
Dec 21, 1989·Nature·C ChothiaW R Tulip
Aug 20, 1987·Journal of Molecular Biology·C Chothia, A M Lesk
Dec 5, 1985·Journal of Molecular Biology·C ChothiaM Karplus
Jan 1, 1969·Annual Review of Biochemistry·G M Edelman, W E Gall
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D M SegalD R Davies
Jul 1, 1995·Journal of Molecular Evolution·F Lara-OchoaJ C Almagro
Jan 1, 1995·Bio Systems·J C AlmagroF Lara-Ochoa
May 1, 1995·Immunology Today·G P Cook, I M Tomlinson
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E W Montroll, M F Shlesinger

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Citations

Nov 9, 2000·European Journal of Immunology·L SpendloveL G Durrant
Jun 7, 2005·Molecular Immunology·Tania Romo-González, Enrique Vargas-Madrazo
Nov 22, 2001·Bio Systems·M del C Ramirez-BenitezJ C Almagro
Nov 12, 2013·Nucleic Acids Research·James DunbarCharlotte M Deane
Sep 15, 2006·Molecular & Cellular Proteomics : MCP·John W KehoeAndrew R M Bradbury
Dec 20, 2018·BMC Structural Biology·Harmeet KaurDinakar M Salunke
Sep 24, 2019·Antibodies·Juan C AlmagroSonia Mayra Pérez-Tapia
Aug 8, 2018·Frontiers in Immunology·Konrad KrawczykCharlotte M Deane
Jul 29, 1998·Journal of Molecular Biology·L CraigJ K Scott

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