Antibody-based immunosuppressive agents for corneal transplantation

Eye
M A ThielK A Williams

Abstract

The progress in antibody engineering over the last 20 years has created the tools for the development of novel antibody-based drugs and constructs, such as small antibody fragments, suitable for topical administration. In rheumatology, oncology, transplantation medicine and ophthalmology, therapeutic antibody constructs, and antibody fragments have been responsible for the clinical progress seen over the last decade. Although antibody-based therapies have become a well-established immunosuppressive option in solid organ transplantation, there are only very few reports with regard to corneal transplantation. The following review explains some of the important aspects of engineered antibody-based therapeutic agents and summarises the current use of such immunosuppressive therapies in transplantation medicine and corneal transplantation.

References

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Citations

Sep 11, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Alvin L YoungSrinivas K Rao
Mar 25, 2016·World Journal of Transplantation·Tian YuLucia Kuffová
Aug 26, 2010·Current Opinion in Allergy and Clinical Immunology

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