Antibody but not memory B-cell responses are tuned-down in vertically HIV-1 infected children and young individuals being vaccinated yearly against influenza

Vaccine
Stefano RinaldiAlberto Cagigi

Abstract

Yearly immunization against seasonal influenza is highly recommended for HIV-1 infected individuals but evaluating the success of vaccination by serological markers may not be fully informative in this population. Recently, it has been hypothesized that the generation of long-lasting immune responses may depend on whether similar antigens challenge the immune system frequently and intermittently. In the present study, in order to search for additional correlates of vaccine-induced protective immunity and to further dissect this theory, both humoral and memory B-cell responses to the trivalent 2012-2013 seasonal influenza vaccination has been evaluated by strain-specific (separately for H1N1, H3N2 and B strain) standard hemagglutination inhibition (HI) assay and B-cell enzyme-linked immunosorbent spot (ELISpot) in a cohort of vertically HIV-1 infected children and young individuals as compared to age-matched healthy controls. A high number of HIV-1 infected individuals had protective antibody levels prior to vaccination and showed low seroconversion rates after vaccination as compared to healthy controls. On the contrary, similar frequencies of influenza-specific memory B-cells were detected by B-cell ELISpot in both groups sugg...Continue Reading

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Citations

Oct 21, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Alberto CagigiPaolo Palma
Apr 19, 2015·Vaccine·Zhiliang HuWei Jiang
Jun 16, 2017·Human Vaccines & Immunotherapeutics·Maria R Castrucci
Dec 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donato AmodioConstantinos Petrovas
Jan 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lesley R de ArmasSavita Pahwa
Apr 6, 2019·ELife·Thomas Pradeu
Oct 19, 2019·Clinical and Experimental Immunology·D AmodioP Palma

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