Antibody changes in paragonimiasis patients after praziquantel treatment as observed by ELISA and immunoblot

Kisaengch'unghak chapchi. The Korean journal of parasitology
S Y ChoY C Han

Abstract

To observe antibody changes after praziquantel treatment in paragonimiasis, a total of 46 serum samples from 13 serologically diagnosed patients was collected for 4-28 months. The specific antibody (IgG) levels were measured by enzyme-linked immunosorbent assay (ELISA). All but one patient who needed retreatment became symptom-free within a week. Antibody levels were dropped near to or below a cut-off absorbance (abs.) of 0.25 in varying intervals from 4 to 18 months. Of 9 patients who were retested within 3 months, 5 revealed temporary elevation of antibody level. After the elevation, the levels began to decline slowly to negative ranges. If treated earlier after symptoms developed, the temporary elevation did not occur and intervals to negative conversion were shorter. By sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)/immunoblot, antigen-antibody reactions in individual patient faded gradually without significant changes in reacting antigen bands.

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Citations

Nov 24, 2011·The Lancet Infectious Diseases·Thomas FürstJürg Utzinger
Oct 23, 1997·The Korean Journal of Parasitology·Y KongS Y Cho
Dec 1, 1990·Kisaengch'unghak chapchi. The Korean journal of parasitology·D W Choi
Sep 1, 1993·The Korean Journal of Parasitology·S I Kim, S Y Cho
Jun 1, 1992·Kisaengch'unghak chapchi. The Korean journal of parasitology·Y KongS Y Cho
Apr 22, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Lan ZhouShaohua Zhu
Jun 1, 1989·Kisaengch'unghak chapchi. The Korean journal of parasitology·S H LeeJ Y Chai
Jul 20, 2017·The Korean Journal of Parasitology·Min Jae KimYong Pil Chong
Jul 17, 1998·Clinical and Diagnostic Laboratory Immunology·Y KongS Y Cho

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