Antibody concentrations against the infecting serotype in vaccinated and unvaccinated children with invasive pneumococcal disease in the United Kingdom, 2006-2013

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Nicholas BrousseauShamez Ladhani

Abstract

This study aimed to estimate, following invasive pneumococcal disease (IPD), the proportion of children with protective immunoglobulin G (IgG) concentrations against the infecting serotype compared with other vaccine serotypes, and to assess risk of recurrent IPD. Pneumococcal antibody concentrations were available for 413 children with vaccine-type IPD diagnosed during 2006-2013. We compared serotype-specific IgG concentrations against the infecting vs other vaccine serotypes, after adjusting for confounders such as age using multilevel analyses. After IPD, a higher proportion of vaccine-naive children had IgG concentrations ≥0.35 µg/mL against their infecting serotype than other vaccine serotypes (51% vs 36%; P < .001). In contrast, among children immunized with pneumococcal conjugate vaccine (PCV) both before and after IPD, the proportion with IgG concentrations ≥0.35 µg/mL against the infecting serotype was lower compared with other vaccine serotypes (71% vs 98%; P < .001). These children also had lower IgG geometric mean concentrations (GMCs) against the infecting serotype (2.22 µg/mL) vs other vaccine serotypes (15.64 µg/mL) in multilevel models (IgG GMC ratio, 0.24; 95% confidence interval, .18-.32), although their IgG G...Continue Reading

References

Mar 29, 2006·The Pediatric Infectious Disease Journal·David GoldblattElizabeth Miller
Aug 24, 2007·The Lancet Infectious Diseases·Katherine L O'BrienDavid Goldblatt
Mar 26, 2011·Expert Review of Vaccines·Bernard Fritzell, Mark A Fletcher
Aug 26, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Anthony G ScottDavid Goldblatt
May 23, 2012·Emerging Infectious Diseases·Elaine StanfordRay Borrow
Dec 25, 2012·Emerging Infectious Diseases·Shamez N LadhaniElizabeth Miller
Nov 22, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P TurnerD Goldblatt
Jul 22, 2014·The Lancet Infectious Diseases·Angel Vila-Corcoles, Olga Ochoa-Gondar

❮ Previous
Next ❯

Citations

Sep 16, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas BrousseauShamez N Ladhani
Sep 16, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M Musher
Jan 9, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Godwin OligbuShamez N Ladhani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.