Jul 1, 1976

Antibody-dependent cell-mediated cytotoxicity in selected autoimmune diseases

The Journal of Clinical Investigation
J L FeldmannN Talal

Abstract

Antibody-dependent cell-mediated cytotoxicity mediated by peripheral blood lymphocytes was studied in patients with systemic lupus erythematosus, polyarteritis nodosa. Sjogren's syndrome, and rheumatoid arthritis. The target cells were chicken erythrocytes coated with rabbit anti-chicken erythrocyte antibody. Antibody-dependent cell-mediated cytotoxic activity was normal in Sjogren's syndrome and rheumatoid arthritis but significantly decreased (P is less than 0.001) in active systemic lupus erythematosus and in two patients with polyarteritis nodosa. A partial regeneration of antibody-dependent cell-mediated cytotoxic activity was obtained by treatment with pronase and DNase followed by overnight incubation. Sera from patients with systemic lupus erythematosus inhibited antibody-dependent cell-mediated cytotoxic activity of normal lymphocytes. The inhibitory activity was studied by specific immunoadsorption and sucrose density geadient ultracentrifugation. Removal of IgG but not IgM greatly reduced inhibition. Inhibitory factors were present in 7S and heavier fractions containing IgG. Five systemic lupus erythematosus patients were studied serially to determine if improvement in clinical status could be correlated with a decre...Continue Reading

Mentioned in this Paper

Deoxyribonuclease I
Infantile Polyarteritis
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Lymphoid Cells
PHGDH
Phosphoglycerate Dehydrogenase Activity
Rheumatoid Arthritis
Specimen Type - Erythrocytes
Autoimmune Diseases

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