Antibody-dependent cellular cytotoxicity in chronic human Chagas disease

Parasite Immunology
J C VoltarelliJ Santana da Silva

Abstract

Antibody-dependent cellular cytotoxicity mediated by granulocytes (ADGC) or lymphocytes (ADLC) was assessed in 23 patients with chronic Chagas disease. The results of ADGC against T. cruzi were normal. ADLC against chicken erythrocytes was significantly reduced in patients as compared with normal controls. Possible causes of this abnormality were investigated.

References

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Citations

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·J C VoltarelliR P Falcao
Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sílvia de Barros-MazonIses A Abrahamsohn
Jul 1, 1995·Parasite Immunology·A B Stracieri, J C Voltarelli
Jul 1, 1990·Revista Do Instituto De Medicina Tropical De São Paulo·J C VoltarelliR P Falcão
Aug 22, 2018·Frontiers in Immunology·Elidiana De BonaIara J de Messias Reason

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Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.