Antibody-dependent enhancement of dengue virus infection in vitro by undiluted sera from monkeys infected with heterotypic dengue virus

Archives of Virology
Mikako ItoIchiro Kurane

Abstract

Two monkeys (Macaca fascicularis) each were infected with dengue virus type 1 (DENV-1) and type 2 (DENV-2). High levels of neutralizing antibody to homotypic serotype were detected from day 10 to week 58 after infection. Levels of cross-reactive neutralizing antibody to other serotypes were at lower levels or undetectable. Serum samples collected from day 10 to week 58 enhanced infection by homotypic and heterotypic serotypes of DENV when diluted, demonstrating antibody-dependent enhancement (ADE). The ADE activities to heterotypic and homotypic dengue virus infections peaked at dilutions of 1:10-1:100 and 1:100-1:1,000, respectively. Serum samples collected enhanced heterotypic dengue virus infection without any dilution. The results indicate that sera from infected monkeys have an ability to enhance heterotypic dengue virus infection in vitro without dilution, although some of these sera also possess neutralizing activity.

References

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Citations

Jun 14, 2013·Applied Microbiology and Biotechnology·Xiao-Quan LiXiao-Yan Che
Jan 9, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Meng Ling MoiIchiro Kurane
Dec 24, 2013·Immunology Letters·Milene Silveira FerreiraPedro Fernando da Costa Vasconcelos
Nov 26, 2013·Vaccine·Isabel Rodriguez-BarraquerDerek A T Cummings
Jan 5, 2019·Reviews in Medical Virology·Ibrahim RadwanNguyen Tien Huy
May 6, 2017·Nature Reviews. Drug Discovery·Veaceslav BoldescuChristian D Klein

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Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.