For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers. By contrast, we observe protection from all symptomatic dengue disease at high antibody titers. Thus, immune correlates of severe dengue must be evaluated separately from correlates of protection against symptomatic disease. These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern.
Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction.
Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever
Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants
Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence
Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak
The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple-strain pathogens
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes
Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva
Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection
High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua
Dengue in Vietnamese infants--results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity
Evaluation of immunological markers in serum, filter-paper blood spots, and saliva for dengue diagnosis and epidemiological studies
The Nicaraguan pediatric dengue cohort study: study design, methods, use of information technology, and extension to other infectious diseases
A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
Dengue plaque reduction neutralization test (PRNT) in primary and secondary dengue virus infections: How alterations in assay conditions impact performance
Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease
High dengue case capture rate in four years of a cohort study in Nicaragua compared to national surveillance data
Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission
Asymptomatic dengue infection in a Cuban population confirms the protective role of the RR variant of the FcgammaRIIa polymorphism
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand
Multicentre prospective study on dengue classification in four South-east Asian and three Latin American countries
Kinetics of viremia and NS1 antigenemia are shaped by immune status and virus serotype in adults with dengue
Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection
Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity
Modelling the long-term persistence of neutralizing antibody in adults after one dose of live attenuated Japanese encephalitis chimeric virus vaccine
Underrecognized mildly symptomatic viremic dengue virus infections in rural Thai schools and villages
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope
Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas
Development of Dengue Virus Serotype-Specific NS1 Capture Assays for the Rapid and Highly Sensitive Identification of the Infecting Serotype in Human Sera
An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels
Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors
Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study
The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis
The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity
Protein Disulfide Isomerase Inhibitor Suppresses Viral Replication and Production during Antibody-Dependent Enhancement of Dengue Virus Infection in Human Monocytic Cells
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
Zika Virus-Specific IgY Results Are Therapeutic Following a Lethal Zika Virus Challenge without Inducing Antibody-Dependent Enhancement
Magnitude and Functionality of the NS1-Specific Antibody Response Elicited by a Live-Attenuated Tetravalent Dengue Vaccine Candidate.
Detection of post-vaccination enhanced dengue virus infection in macaques: An improved model for early assessment of dengue vaccines
Bridging Efficacy of a Tetravalent Dengue Vaccine from Children/Adolescents to Adults in Highly Endemic Countries Based on Neutralizing Antibody Response
The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design.
The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases
Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features
Dengue viral infection in Indonesia: Epidemiology, diagnostic challenges, and mutations from an observational cohort study
Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
Dengue virus non-structural protein 1 activates the p38 MAPK pathway to decrease barrier integrity in primary human endothelial cells
Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures.
Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases.
Dengue Virus-Specific Humoral and T Cellular Immune Response in Italian Residents and Travelers Returning from Endemic Areas.
Primary and Secondary Dengue Virus Infections Elicit Similar Memory B-Cell Responses, but Breadth to Other Serotypes and Cross-Reactivity to Zika Virus Is Higher in Secondary Dengue.
Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.