Antibody drug conjugates: Progress, pitfalls, and promises

Human Antibodies
Anubhab MukherjeeVenkata Mahidhar Yenugonda

Abstract

Antibody drug conjugates (ADCs) represent a promising and an efficient strategy for targeted cancer therapy. Comprised of a monoclonal antibody, a cytotoxic drug, and a linker, ADCs offer tumor selectively, reduced toxicity, and improved stability in systemic circulation. Recent approvals of two ADCs have led to a resurgence in ADC research, with more than 60 ADCs under various stages of clinical development. The therapeutic success of future ADCs is dependent on adherence to key requirements of their design and careful selection of the target antigen on cancer cells. Here we review the main components in the design of antibody drug conjugates, improvements made, and lessons learned over two decades of research, as well as the future of third generation ADCs.

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Citations

Sep 10, 2019·Expert Opinion on Drug Delivery·Sadia SikderDhananjay Pal
Aug 28, 2019·Nature Chemical Biology·Heather A Van Epps, Peter D Senter
Nov 12, 2019·Frontiers in Pharmacology·Vijay Sagar MadamsettySudip Mukherjee
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May 1, 2019·Cancers·Anubhab MukherjeeSudip Mukherjee
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Aug 25, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dipesh UpretyAlex A Adjei
Oct 2, 2021·Drug Discovery Today·Md Mahbub HasanKhondaker Miraz Rahman

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