Antibody efficacy in murine pulmonary Cryptococcus neoformans infection: a role for nitric oxide

The Journal of Immunology : Official Journal of the American Association of Immunologists
Johanna RiveraA Casadevall

Abstract

We investigated the pathogenesis of pulmonary Cryptococcus neoformans infection and passive Ab efficacy in mice deficient in inducible NO synthase (NOS2(-/-)) and the parental strain. Parental mice lived significantly longer than NOS2(-/-) mice after intratracheal infection, despite having a higher lung fungal burden. Administration of Ab reduced lung CFU in both NOS2(-/-) and parental mice, but prolonged survival and increased the inflammatory response only in parental mice. Ab administration was associated with increased serum nitrite and reduced polysaccharide levels in parental mice. Eosinophils were present in greater numbers in the lung of infected NOS2(-/-) mice than parental mice, irrespective of Ab administration. C. neoformans infection in NOS2(-/-) mice resulted in significantly higher levels of IFN-gamma, monocyte chemoattractant protein-1, and macrophage-inflammatory protein-1alpha than parental mice. Ab administration had different effects on infected NOS2(-/-) and parental mice with respect to IFN-gamma, monocoyte chemoattractant protein-1, and macrophage-inflammatory protein-1alpha levels. Ab administration increased lung levels of IFN-gamma in parental mice and reduced levels in NOS2(-/-) mice. The results indi...Continue Reading

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Citations

Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos P TabordaArturo Casadevall
Sep 12, 2013·Future Microbiology·Ruth A BryanEkaterina Dadachova
Feb 24, 2016·Frontiers in Microbiology·Chrissy M Leopold WagerFloyd L Wormley
Nov 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Raju C ReddyTheodore J Standiford
Feb 14, 2007·Infection and Immunity·Matthew MarksLiise-anne Pirofski
Apr 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Krishanthi S SubramaniamLiise-Anne Pirofski
Sep 21, 2013·Annual Review of Pathology·Carolina CoelhoArturo Casadevall
Oct 27, 2010·PLoS Neglected Tropical Diseases·Livia C L LopesEliana Barreto-Bergter
Nov 19, 2014·Seminars in Immunopathology·Sri Ramulu ElluruJagadeesh Bayry
May 30, 2019·Microbiology·Maria MaryamCarolina Coelho
Jan 21, 2006·Medical Mycology·Arturo Casadevall, Liise-Anne Pirofski
Mar 9, 2005·The Journal of Experimental Medicine·Suzanne A MilesDavid M Mosser
Oct 27, 2004·Infection and Immunity·Arturo Casadevall, Liise-anne Pirofski
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johanna Rivera, Arturo Casadevall
Oct 12, 2018·Ocular Immunology and Inflammation·Xuedong ZhengJianzhang Hu
Jul 16, 2003·Annals of the New York Academy of Sciences·Gary M WinslowJulia Shu-Yi Li
Oct 26, 2013·Expert Review of Vaccines·Ashok K Chaturvedi, Floyd L Wormley
Sep 10, 2014·Parasite Immunology·A Rivera
Mar 4, 2020·Journal of Fungi·Camila BonicheCarlos Pelleschi Taborda
Aug 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magdia De JesusArturo Casadevall
Aug 27, 2019·Innate Immunity·Patrícia Kellen Martins Oliveira-BritoThiago Aparecido da Silva
May 12, 2017·Cell Host & Microbe·Aseem PandeyPaul de Figueiredo
Aug 6, 2002·Current Opinion in Microbiology·Michael K Mansour, Stuart M Levitz
Sep 4, 2004·Journal of Immunological Methods·Arturo Casadevall
Sep 5, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristie D GoughenourMichal A Olszewski

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