Antibody feedback regulation in vitro: T helper cell activation and T-B cell cooperation are not impaired by anti-carrier antibody

European Journal of Immunology
R H Zubler

Abstract

Effects of antibody feedback regulation on T helper (Th) cell functions required in plaque-forming cell (PFC) responses were studied in vitro. Using a sensitive functional assay, it was found that serum from immunized mice did not inhibit sheep erythrocyte (SRBC)-, or keyhole limpet hemocyanin-specific Th cell activation. SRBC-"pulsed" splenic adherent cells activated Th cells more efficiently when pulsed in the presence of anti-SRBC antiserum. PFC responses against, 2,4,6-trinitrophenyl (TNP) coupled to soluble carriers were studied under conditions in which linkage between hapten and the priming carrier was either required or not. Under both conditions, anti-carrier antiserum had an enhancing or no effect; only anti-hapten antiserum or monoclonal anti-hapten antibody were inhibitory. Thus, these results did show that antibody feedback was essentially hapten-specific and did not interfere with Th cell functions, except, possibly, that anti-hapten antibody interfered with linked cooperation at the level of hapten-B cell interaction, in addition to its inhibitory effect detectable under conditions of unlinked cooperation. Since SRBC-pulsed, adherent cells were very inefficient in stimulating anti-SRBC PFC responses, the results ...Continue Reading

References

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