Antibody formation in mouse bone marrow during secondary type responses to various thymus-independent antigens

Immunobiology
G KochR Benner

Abstract

The data presented in this paper show that different thymus-independent (TI) antigens have a differential capacity of inducing antibody formation in mouse bone marrow, both after primary and secondary intravenous immunization. Primary immunization with certain TI antigens (e.g., lipopolysaccharide [LPS], TNP-LPS, DNP-Ficoll) induces the appearance of antibody-forming cells not only in the spleen, but also in the bone marrow. A single injection of certain other TI antigens (e.g., pneumococci [Pn], TNP-conjugated detoxified LPS [TNP-dLPS], TNP-conjugated Brucella abortus bacteria [TNP-BA] ), on the other hand, induces antibody formation in the spleen only. After secondary immunization with these TI antigens only TNP-BA induces a PFC response in the bone marrow. Pn, TNP-dLPS and TNP-BA, but also DNP-Ficoll, are unable to induce bone marrow antibody formation after secondary injection of the antigen, in spite of the clear-cut secondary type character of the splenic response. Thus, the absence of a bone marrow PFC response after secondary immunization with these antigens is not due to a failure to induce memory B cells. This data implies that either two subpopulations of memory B cells exist, one giving rise to antibody formation in...Continue Reading

References

Jul 1, 1977·The Journal of Experimental Medicine·G K Lewis, J W Goodman
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Jun 2, 1971·Nature: New Biology·J H Playfair, E C Purves

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Citations

May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xin Yu WangHiroshi Kiwada
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A A Geldof, H L Langevoort
Oct 1, 1986·European Journal of Immunology·F HoM Khan
Oct 1, 1986·Immunological Reviews·D G Osmond
Jun 1, 1986·Immunological Reviews·I C MacLennan, D Gray

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