PMID: 9420730Sep 1, 1994Paper

Antibody imaging in the evaluation of cardiovascular diseases

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
B A Khaw, J Narula

Abstract

Antimyosin antibody was originally developed for in vivo detection of acute myocardial infarction. However, its utility has expanded to include diagnosis of various cardiovascular diseases in which myocyte necrosis constitutes an obligatory component of the disease. Thus antimyosin has also been used clinically for noninvasive diagnosis of acute myocarditis, heart transplant rejection, drug-induced cardiotoxicity, and other cardiomyopathies. This first-generation monoclonal antibody, antimyosin, has opened the way for the second-generation monoclonal antibodies such as antifibrin and antiplatelet for in vivo diagnostic use in the detection of deep venous thrombosis and pulmonary embolism and antiatherosclerotic lesion-specific antibody for diagnosis of metabolically active lesions. Whether the third generation of antibodies will include ultrasmall antigen-binding units or negative charge-modified antibodies must await future studies.

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Citations

Oct 1, 2013·Current Heart Failure Reports·Manojkumar RohitK K Talwar
Mar 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·I Carrió, M Ballester
Mar 10, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J LekakisS Stamatelopoulos
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael PhillipsMark J Zucker
May 26, 2004·Cardiology Clinics·Flordeliza S VillanuevaJagat Narula

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