PMID: 11926747Apr 3, 2002Paper

Antibody inhibition of cytomegalovirus: the role of natural killer and macrophage effector cells

Transplant Infectious Disease : an Official Journal of the Transplantation Society
D N ForthalG Landucci

Abstract

To explore mechanisms by which antibody might inhibit cytomegalovirus (CMV), we measured the ability of intravenous CMV-IgG (CytoGam) to reduce viral yield in the presence of effector cells. Foreskin fibroblasts were infected with a clinical strain of CMV, and CytoGam was added along with effector cells consisting of either unfractionated peripheral blood mononuclear cells (PBMCs), natural killer (NK) cells, or macrophages. The combination of CytoGam and either of the effector cell types markedly inhibited established CMV infection in vitro. In addition, CytoGam combined with effector cells protected the monolayer from CMV-induced cytopathic effects. Antibody-dependent, effector cell-mediated functions may underlie the ability of CytoGam to prevent or modulate CMV infection in vivo.

Citations

Mar 7, 2020·The Journal of Infectious Diseases·Cody S NelsonSallie R Permar
Feb 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcel Costa-GarciaAura Muntasell
May 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Cody S NelsonSallie R Permar
Aug 28, 2021·International Journal of Molecular Sciences·Evi B StrubleDorothy Scott

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