Antibody isotype responses to the Schistosoma mansoni schistosomulum in the CBA/N mouse induced by different stages of the parasite life cycle

Parasite Immunology
G MazzaA E Butterworth

Abstract

During infection with Schistosoma mansoni the extent and nature of immune reactions against schistosomula may be influenced by responses to cross-reactive antigens in eggs or adult worms, and there is now extensive evidence for cross-reactivity between the different stages of the parasite life cycle. In this study IgM and IgG subclass antibodies produced in (CBA/N x Balb/c) F1 male and female mice were measured over a period of time following exposure to a chronic infection, to unisexual male cercariae or to irradiated larvae. Antibody levels were also measured following immunization with antigen preparations derived from adult worms, schistosomula or eggs. (CBA/N x Balb/c) F1 male mice exhibit an X-linked immune deficiency which results in an inability to respond to T-independent (TI) type 2 polysaccharides. Isotype levels were measured by ELISA to detergent-soluble schistosomulum antigen. Results showed that antigens on the different stages of the parasite life cycle have a qualitative influence on the antibody response to the larval surface, and that T-independent type 2 polysaccharides, particularly abundant in egg, exhibit antigen-directed isotype restriction in the form of IgM and IgG3 antibodies.

References

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Citations

Feb 1, 1990·Parasitology Today·D W Dunne
Jun 10, 1995·Lancet·D W DunneF G Abath
Aug 1, 1992·Immunological Investigations·A E ButterworthR F Sturrock
May 17, 2015·Medical Mycology·Iain D PageDavid W Denning
Oct 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M Haas
Jul 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas W KinJohn F Kearney
Sep 19, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Ariel SpurrierKaren M Haas

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