Antibody Levels and Protection After Hepatitis B Vaccine: Results of a 30-Year Follow-up Study and Response to a Booster Dose

The Journal of Infectious Diseases
Michael G BruceBrian J McMahon

Abstract

The duration of protection in children and adults resulting from hepatitis B vaccination is unknown. In 1981, we immunized a cohort of 1578 Alaska Native adults and children from 15 Alaska communities aged ≥6 months using 3 doses of plasma-derived hepatitis B vaccine. Persons were tested for antibody to hepatitis B surface antigen (anti-HBs) levels 30 years after receiving the primary series. Those with levels <10 mIU/mL received 1 booster dose of recombinant hepatitis B vaccine 2-4 weeks later and were then evaluated on the basis of anti-HBs measurements 30 days after the booster. Among 243 persons (56%) who responded to the original primary series but received no subsequent doses during the 30-year period, 125 (51%) had an anti-HBs level ≥10 mIU/mL. Among participants with anti-HBs levels <10 mIU/mL who were available for follow-up, 75 of 85 (88%) responded to a booster dose with an anti-HBs level ≥10 mIU/mL at 30 days. Initial anti-HBs level after the primary series was correlated with higher anti-HBs levels at 30 years. Based on anti-HBs level ≥10 mIU/mL at 30 years and an 88% booster dose response, we estimate that ≥90% of participants had evidence of protection 30 years later. Booster doses are not needed.

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Citations

Jan 24, 2016·The Journal of Infectious Diseases·Pierre Van Damme
Jul 31, 2016·Public Health·M BruceA Koch
Sep 27, 2016·Human Vaccines & Immunotherapeutics·Jose Ignacio VargasFrancisco Fuster
Oct 16, 2016·Clinics in Liver Disease·Noele P NelsonBrian J McMahon
Jun 22, 2016·Scientific Reports·Shigui YangLanjuan Li
Mar 13, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S HustacheO Epaulard
Mar 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Abhishek WattsMarian D Pfefferkorn
Sep 3, 2017·Journal of Immigrant and Minority Health·Deborah LeeYecai Liu
Aug 9, 2017·The Pediatric Infectious Disease Journal·Jodie Dionne-OdomAlan T N Tita
Sep 28, 2018·International Journal of Clinical Practice·Ellen M Einterz
Jan 10, 2019·Expert Review of Clinical Pharmacology·Lung-Yi MakMan-Fung Yuen
Jun 26, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Sarah SchillieNoele P Nelson
Aug 31, 2019·Current HIV/AIDS Reports·Priya D Farooq, Kenneth E Sherman
Dec 18, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Haruki KomatsuRobert Thimme
Mar 13, 2020·Journal of Paediatrics and Child Health·Michael E Jones, Joanna M Tully
Mar 19, 2020·Human Vaccines & Immunotherapeutics·Hong ZhaoYi-Hua Zhou
Nov 7, 2019·Human Vaccines & Immunotherapeutics·Timo VesikariAndrew Wen-Tseng Lee
Aug 12, 2016·Infectious Diseases of Poverty·Nowrozy Kamar JahanSharifah SyedHassan
Jul 28, 2018·Biomedicines·Marija Vujadinovic, Jort Vellinga
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Aug 2, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Valéria Maciel CordeiroMegmar Aparecida Dos Santos Carneiro

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