PMID: 9544413Apr 17, 1998Paper

Antibody levels in Ethiopian children five years after vaccination with two different doses of hepatitis B vaccine: is there a need for booster vaccine?

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
E TsegaJ Lindberg

Abstract

It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 micrograms hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 micrograms doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested.

Citations

Oct 16, 2015·World Journal of Hepatology·Iman I SalamaAmmal M Metwally
Jun 7, 2017·Expert Review of Vaccines·Caroline van den EndeLaurence De Moerlooze

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