Antibody-mediated complement activation in pathology and protection.

Immunology and Cell Biology
Benjamin S Goldberg, Margaret E Ackerman

Abstract

Antibody-dependent complement activity is associated not only with autoimmune morbidity, but also with antitumor efficacy. In infectious disease, both recombinant monoclonal antibodies and polyclonal antibodies generated in natural adaptive responses can mediate complement activity to protective, therapeutic or disease-enhancing effect. Recent advances have contributed to the structural resolution of molecular complexes involved in antibody-mediated complement activation, defining the avid nature of participating interactions and pointing to how antibody isotype, subclass, hinge flexibility, glycosylation state, amino acid sequence and the contextual nature of the cognate antigen/epitope are all factors that can determine complement activity through impact on antibody multimerization and subsequent recruitment of complement component 1q. Beyond the efficiency of activation, complement activation products interact with various cell types that mediate immune adherence, trafficking, immune education and innate functions. Similarly, depending on the anatomical location and extent of activation, complement can support homeostatic restoration or be leveraged by pathogens or neoplasms to enhance infection or promote tumorigenic microe...Continue Reading

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S N IsaacsB Moss
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L K TanS L Morrison
Oct 1, 1988·European Journal of Immunology·C I BindonH Waldmann
Dec 9, 1998·Clinical and Experimental Immunology·B P Morgan, A Orren
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E E IdusogieM G Mulkerrin
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D MastellosJ D Lambris
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola Di GaetanoJosée Golay
Dec 2, 2005·Expert Opinion on Biological Therapy·Kyra A GeldermanArko Gorter
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L TeelingJan G J van de Winkel
Sep 23, 2006·The New England Journal of Medicine·Peter HillmenLucio Luzzatto
May 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Falk NimmerjahnJeffrey V Ravetch
Jul 3, 2007·British Journal of Pharmacology·P N MonkD P Fairlie
Jul 24, 2007·The Journal of Biological Chemistry·Oren Moskovich, Zvi Fishelson
Sep 5, 2007·Molecular Immunology·Martin J GlennieRonald P Taylor
Nov 17, 2007·Cell Host & Microbe·Theodore C PiersonMichael S Diamond
Sep 30, 2008·Nature Immunology·Maciej M MarkiewskiJohn D Lambris
Nov 21, 2008·Journal of Virology·Mohammed Rafii-El-Idrissi BenhniaShane Crotty
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephen L SazinskyK Dane Wittrup
Jul 30, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·N YukiP J Späth
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Feb 3, 2012·Kidney International·Danielle CohenIngeborg M Bajema
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frank J BeurskensRonald P Taylor
Apr 3, 2012·Archives of Biochemistry and Biophysics·Roy Jefferis
Oct 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leticia CorralesRuben Pio
Apr 27, 2013·The Journal of Clinical Investigation·Joshua M ThurmanV Michael Holers
Jun 7, 2013·The New England Journal of Medicine·C M LegendreC Loirat

❮ Previous
Next ❯

Citations

Nov 1, 2020·Antibodies·Josée Golay, Ronald P Taylor
Nov 7, 2020·Clinical and Experimental Immunology·N VukovicD M W Zaiss
Mar 24, 2021·Expert Opinion on Therapeutic Targets·Simone I Richardson, Penny L Moore
Jul 1, 2020·Terapevticheskiĭ arkhiv·E L NasonovZ S Alekberova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.