Antibody-mediated enhancement of hormone activity

Molecular Immunology
R AstonG L Ada


The enhancement of hormone activity by antibodies has been known for many years; however, investigation into the molecular basis of the phenomenon has only recently begun. A number of mechanisms for this enhancement, including "buffering" or slow release, bivalency and Fc region, and conformational and receptor "restriction" effects, have been documented or proposed. The availability of panels of monoclonal antibodies of distinct combining site specificity have aided in these studies and contributed substantially to our understanding of hormone-receptor interactions.


Jan 12, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·A A Mart'ianovI P Ashmarin
Nov 19, 2003·Indian Journal of Pediatrics·Tirang R NeyestaniAli Keshavarz
Sep 1, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Terry L Derting, Maninder K Virk
Apr 1, 1995·Molecular Immunology·L P RoguinL A Retegui
Apr 18, 2001·Molecular and Cellular Endocrinology·D Burbridge, M Wallis
Jan 24, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·C Secchi, V Borromeo
Feb 14, 2009·Cytokine & Growth Factor Reviews·Carina de Lemos RieperMorten Bagge Hansen
Sep 26, 2003·Scandinavian Journal of Immunology·L P Roguin, L A Retegui
Jul 5, 2005·Expert Opinion on Investigational Drugs·J Beattie, David J Flint
Apr 7, 2009·Regulatory Toxicology and Pharmacology : RTP·Rafael PonceDan Wierda
Apr 1, 1995·Journal of Pediatric Endocrinology & Metabolism : JPEM·B K SuhA W Root
Dec 3, 2008·Advances in Physiology Education·Rodney A HillJennifer M Pell


Jul 9, 1977·Lancet·A B KurtzJ D Nabarro
Nov 17, 1975·Biochemical and Biophysical Research Communications·U J LewisW P Vanderlaan
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C R KahnJ S Flier
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Y ShechterP Cuatrecasas
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M WilchekY J Topper
Jan 1, 1985·Pharmacology & Therapeutics·R Aston, J Ivanyi
Apr 1, 1986·Molecular Immunology·D A Rathjen, P A Underwood
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J GariépyG K Schoolnik
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H M GeysenR H Meloen
Jul 1, 1985·The Journal of Clinical Endocrinology and Metabolism·E MoyseA Enjalbert
Oct 1, 1988·Protein Engineering·I S DunnP A Jennings
Sep 1, 1988·The Proceedings of the Nutrition Society·R AstonR Bomford
Mar 6, 1987·Science·H M GeysenR A Lerner
Jan 1, 1985·The Journal of Endocrinology·R G ClarkI C Robinson
Aug 1, 1985·Molecular Immunology·H M CooperS J Leach
Dec 1, 1985·The Journal of Endocrinology·A T HolderJ Ivanyi
Feb 12, 1972·Lancet·K DixonH R Hughes
May 1, 1970·The Journal of Clinical Endocrinology and Metabolism·T L GoodfriendJ S McGuire
Oct 23, 1974·Biochemical and Biophysical Research Communications·B K Vonderhaar, Y J Topper
Dec 1, 1980·European Journal of Immunology·M PierresD Caillol
Jan 1, 1982·Immunological Communications·C R Young, M Z Atassi
Feb 11, 1983·Science·J G SutcliffeR A Lerner
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H L NimanR A Lerner
Sep 1, 1983·European Journal of Immunology·J A SchroerK J Kim
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L J Van EldikD M Watterson

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