PMID: 7007708Sep 1, 1980Paper

Antibody-mediated injury to proximal tubules in Heymann nephritis

Kidney International
D L MendrickG A Andres

Abstract

To evaluate the hypothesis that antibody-mediated damage to proximal tubules (PT) could be a feature of Heymann nephritis (HN), we studied the kidneys of rats in different stages of the disease by light, immunoflourescence (IF), transmission, and scanning electron microscopy. The observations of morphology were correlated with titers of circulating antibodies directed against the brush border (BB) and with proteinuria. Antibody titers reached a maximum 5 to 7 weeks after immunization with Fx1A, coincident with the onset of proteinuria. IgG and C3 were deposited along the BB of PT in all animals within the first week of proteinuria. BB antibodies were present in the urine of those rats. As antibody titers declined, a decrease in the extent of in vivo IgG deposition along the BB was also noted. The results of indirect IF tests, by using BB antibodies on kidneys of rats with HN of 3 to 4 months' duration, suggested extensive loss of the BB antigen(s) from the PT. Numerous granular deposits of IgG were present along the basement membrane of PT at that time. Study of kidney histology revealed that deposition of IgG and C3 along the BB of PT was associated with extensive loss of microvilli, as well as degeneration and proliferation o...Continue Reading

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Citations

Jan 1, 1982·Springer Seminars in Immunopathology·J R BrentjensG A Andres
Jan 9, 2013·Clinical Reviews in Allergy & Immunology·Arpad Zsigmond BarabasDonald Mackay Weir
Oct 11, 2005·Autoimmunity Reviews·Arpad Zsigmond Barabas, Rene Lafreniere
Sep 4, 2015·Journal of the American Society of Nephrology : JASN·Ivy A RosalesRobert B Colvin
Jan 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K KitazawaB Noble
Mar 1, 1991·Kidney International·C B Wilson
Jun 1, 1990·Kidney International·M J Zamlauski-TuckerB Noble
Aug 1, 1995·Kidney International·L BianconeI Stamenkovic
Apr 1, 1989·Kidney International·J R Brentjens, G Andres
Nov 1, 1988·Kidney International·A FukatsuG Andres
Aug 1, 1987·Kidney International·L PelletierP Druet
Sep 1, 1985·Kidney International·M J Zamlauski-TuckerB Noble
Feb 1, 1985·Kidney International·E de HeerL A van Es
Jun 1, 1987·Kidney International·F B GabbaiR C Blantz
Apr 1, 1988·Kidney International·F N Hutchison, G A Kaysen
Dec 1, 1991·Kidney International·J L OgrodowskiW Kolb
Sep 24, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
Aug 18, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
Nov 30, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
Jan 30, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
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Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M TokumotoM Fujishima
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Aug 1, 1989·The American Journal of Physiology·E J GutmannD Brown
Feb 1, 1984·Clinical Immunology and Immunopathology·B NobleJ R Brentjens

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