Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects.

Adipocyte
Valentina SicaGuido Kroemer

Abstract

We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel 'hunger factor': a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity. Conversely, neutralization of ACBP/DBI by systemic injection of neutralizing monoclonal antibodies or autoantibodies produced after auto-immunization against ACBP/DBI has anorexigenic and lipolytic effects. Thus, neutralization of ACBP/DBI results in reduced food intake subsequent to the activation of anorexigenic neurons and the inactivation of orexigenic neurons in the hypothalamus. Moreover, ACBP/DBI neutralization results into enhanced triglyceride lipolysis in white fat, a surge in free fatty acids in the plasma, enhanced incorporation of glycerol-derived carbon atoms into glucose, as well as an increase in β-oxidation, resulting in a net reduction of fat mass. Importantly, ACBP/DBI neutralization also stimulated an increase in autophagy in various organs, suggesting that it might mediate anti-ageing effects.

References

Sep 3, 2011·Cell·David C RubinszteinGuido Kroemer
Aug 16, 2016·Cell·Carlos López-OtínGuido Kroemer
Oct 12, 2018·Nature Reviews. Molecular Cell Biology·Lorenzo GalluzziGuido Kroemer
Oct 20, 2018·Cell·Guido KroemerRafael de Cabo
Jan 12, 2019·Cell·Beth Levine, Guido Kroemer
Jun 6, 2019·Nature Reviews. Molecular Cell Biology·Carlos Lopez-Otín, Guido Kroemer
Oct 12, 2019·Cell Death & Disease·José Manuel Bravo-San PedroGuido Kroemer
Nov 7, 2019·Molecular & Cellular Oncology·José Manuel Bravo-San PedroGuido Kroemer
Dec 5, 2019·Cell Metabolism·José M Bravo-San PedroGuido Kroemer
Jan 8, 2020·Cell Death & Disease·Nikolaos CharmpilasGuido Kroemer

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