Antibody-mediated red blood cell agglutination resulting in spontaneous echocardiographic contrast

Pediatric Cardiology
M R MillerP J Spevak


Spontaneous echocardiographic contrast is well reported in states of low flow and low shear stress, and the primary blood component involved has been reported as red blood cells via rouleaux formation. This report describes the occurrence of spontaneous echocardiographic contrast from a unique mechanism of IgM-mediated red blood cell agglutination and describes the clinical sequelae.

Related Concepts

Anemia, Hemolytic, Idiopathic Acquired
Low Cardiac Output Syndrome
2D Echocardiography
Rouleaux Formation, Erythrocyte
Fatal Outcome

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.