Antibody-Mediated Rejection After Liver Transplant

Gastroenterology Clinics of North America
Michael Lee

Abstract

Antibody-mediated rejection (AMR) in liver transplants is a field in its infancy compared with its allograft cohorts of the kidney and lung. Acute AMR is diagnosed based on specific clinical and histopathologic criteria: serum donor specific antibodies, C4d staining, histopathologic findings on liver biopsy, and exclusion of other entities. In contrast, the histologic features of chronic AMR are not as specific and it is a more challenging diagnosis to make. Treatments of acute and chronic AMR include some combination of steroids, immune-modulating agents, intravenous immunoglobulin, plasmapheresis, and proteasome inhibitors.

Citations

Aug 1, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Jennifer A McCaughan, Kathryn J Tinckam
Mar 9, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Surumi ShajahanUma Devi Padma
Mar 11, 2020·Journal of Clinical Medicine·Isabel LegazManuel Muro
Feb 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katelynn Madill-ThomsenPhilip F Halloran
Nov 13, 2020·Expert Opinion on Biological Therapy·Bonnie E Lonze
Jun 17, 2020·The Journal of Surgical Research·Rachel HogenJuliet Emamaullee
May 20, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Carme BaliellasJoan Fabregat
Jun 29, 2021·Seminars in Liver Disease·Kristel K LeungAliya Gulamhusein
Jul 17, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Simin Dashti-KhavidakiMohammad Taher

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