Antibody persistence 5 years after vaccination at 2 to 10 years of age with Quadrivalent MenACWY-CRM conjugate vaccine, and responses to a booster vaccination

Vaccine
Stan L BlockIgor Smolenov

Abstract

In a multi-center extension study, children 2-10 years of age, initially vaccinated with one or two doses (2-5 year-olds) or one dose (6-10 year-olds) of quadrivalent meningococcal CRM197-conjugate vaccine (MenACWY-CRM), were assessed five years later for antibody persistence and booster response using serum bactericidal assay with human complement (hSBA). Children 7-10 and 11-15 years of age, who received MenACWY-CRM in the original study, and age-matched vaccine-naïve children, were enrolled in this extension study. After an initial blood draw, children received one dose of MenACWY-CRM as booster or primary dose, with a second blood draw 28 days later. hSBA titers decreased five years after primary vaccination, but were higher than in non-vaccinated controls against serogroups C, W and Y, with substantial proportions having titers ≥8: 7-22% for A, 32-57% for C, 74-83% for W, and 48-54% for Y. Previously-vaccinated children demonstrated booster responses to revaccination against all four serogroups. Responses to primary vaccination in vaccine-naïve controls were lower and similar to primary responses observed in the original study. All vaccinations were generally well tolerated, with no safety concern raised. Approximately hal...Continue Reading

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Citations

May 10, 2016·Expert Review of Vaccines·Giulia PicciniEmanuele Montomoli
Sep 11, 2018·Expert Review of Vaccines·Pavitra KeshavanMichael Nissen
Aug 14, 2019·Clinical and Experimental Vaccine Research·Hoan-Jong LeeMichele Pellegrini
Oct 8, 2020·Microorganisms·Mariagrazia PizzaRino Rappuoli
Aug 31, 2018·Science Translational Medicine·Rino Rappuoli
Jan 9, 2021·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Sarah A MbaeyiJessica R MacNeil

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