PMID: 4000699Mar 1, 1985Paper

Antibody response against schistosomulum surface antigens and protective immunity following immunization with highly irradiated cercariae of Schistosoma mansoni

Parasite Immunology
A J SimpsonS R Smithers


The production of antibodies against the schistosomulum surface antigens of Schistosoma mansoni in response to immunization with highly irradiated cercariae was followed. Four antigens were reproducibly identified by 125I surface labelling using Iodogen and immunoprecipitation; they had mol. wts of 38, 32, 20 and 15 kD. In addition a 92 kD antigen was also evident in most experiments. It was demonstrated that the 20 kD antigen was the same as that recognized by the monoclonal antibody NIMP/M.47 and that this antigen like the 38 and 32 kD antigens was thus identified during both chronic infection and following vaccination with irradiated cercariae. Two weeks following immunization with irradiated cercariae antibody was produced only against the 15 kD antigen but at 4 weeks the major response was against the 32 kD antigen. A second immunization with irradiated cercariae boosts the antibody response so that all four antigens were strongly precipitated. Further vaccinations did not lead to the identification of further antigens. Immunization of rats with highly irradiated cercariae also resulted in antibody production against the 38, 32, 20 and 15 kD antigens. Surface labelling of schistosomula transformed from irradiated cercariae...Continue Reading


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Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·P HaganS R Smithers
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Oct 1, 1989·Experimental Parasitology·S MillerP T LoVerde
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Nov 15, 1985·European Journal of Biochemistry·G Payares, J G Simpson
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