PMID: 4000699Mar 1, 1985Paper

Antibody response against schistosomulum surface antigens and protective immunity following immunization with highly irradiated cercariae of Schistosoma mansoni

Parasite Immunology
A J SimpsonS R Smithers

Abstract

The production of antibodies against the schistosomulum surface antigens of Schistosoma mansoni in response to immunization with highly irradiated cercariae was followed. Four antigens were reproducibly identified by 125I surface labelling using Iodogen and immunoprecipitation; they had mol. wts of 38, 32, 20 and 15 kD. In addition a 92 kD antigen was also evident in most experiments. It was demonstrated that the 20 kD antigen was the same as that recognized by the monoclonal antibody NIMP/M.47 and that this antigen like the 38 and 32 kD antigens was thus identified during both chronic infection and following vaccination with irradiated cercariae. Two weeks following immunization with irradiated cercariae antibody was produced only against the 15 kD antigen but at 4 weeks the major response was against the 32 kD antigen. A second immunization with irradiated cercariae boosts the antibody response so that all four antigens were strongly precipitated. Further vaccinations did not lead to the identification of further antigens. Immunization of rats with highly irradiated cercariae also resulted in antibody production against the 38, 32, 20 and 15 kD antigens. Surface labelling of schistosomula transformed from irradiated cercariae...Continue Reading

References

Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Dec 1, 1974·Experimental Parasitology·F J Ramalho-PintoJ Pellegrino
Mar 1, 1984·Molecular and Biochemical Parasitology·M Philipp, F D Rumjaneck
Aug 1, 1981·Experimental Parasitology·S Y HsüL F Burmeister
Aug 1, 1981·Molecular and Biochemical Parasitology·C DissousA Capron

Citations

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·P HaganS R Smithers
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J SimpsonS R Smithers
Oct 1, 1987·Molecular and Biochemical Parasitology·M Q KlinkertE Beck
Feb 1, 1987·International Journal for Parasitology·S R Smithers
May 12, 2009·Molecular and Biochemical Parasitology·Xinzhi WangJiaojiao Lin
Oct 1, 1989·Experimental Parasitology·S MillerP T LoVerde
Dec 1, 1985·Experimental Parasitology·C KellyS R Smithers
Nov 15, 1985·European Journal of Biochemistry·G Payares, J G Simpson
Jun 1, 1985·Parasitology·A J SimpsonS R Smithers
Jul 18, 2009·Applied Microbiology and Biotechnology·Hyung-Moo JungJung-Kul Lee

Related Concepts

Iodo-Gen
Antibody Formation
Antigens, Helminth
Surface Antigens
Cobalt Radioisotopes
Variolation
Lactoperoxidase
Mice, Inbred CBA
Chemical Precipitation
Radioimmunoassay

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