Antibody response patterns in chikungunya febrile phase predict protection versus progression to chronic arthritis.

JCI Insight
Kaustuv NayakKaja Murali-Krishna

Abstract

Chikungunya virus (CHIKV) infection causes acute febrile illness in humans, and some of these individuals develop a debilitating chronic arthritis that can persist for months to years for reasons that remain poorly understood. In this study from India, we characterized antibody response patterns in febrile chikungunya patients and further assessed the association of these initial febrile-phase antibody response patterns with protection versus progression to developing chronic arthritis. We found 5 distinct patterns of the antibody responses in the febrile phase: no CHIKV binding or neutralizing (NT) antibodies but PCR positive, IgM alone with no NT activity, IgM alone with NT activity, IgM and IgG without NT activity, and IgM and IgG with NT activity. A 20-month follow-up showed that appearance of NT activity regardless of antibody isotype or appearance of IgG regardless of NT activity during the initial febrile phase was associated with a robust protection against developing chronic arthritis in the future. These findings, while providing potentially novel insights on correlates of protective immunity against chikungunya-induced chronic arthritis, suggest that qualitative differences in the antibody response patterns that have...Continue Reading

References

Jan 1, 1992·Archives of Dermatological Research·M DmochowskiT Nishikawa
Jun 27, 2006·Vector Borne and Zoonotic Diseases·Stephen Higgs
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Erin StaplesAnn M Powers
Aug 23, 2011·PLoS Neglected Tropical Diseases·Alyson A KelvinSalvatore Rubino
Jul 3, 2013·Antiviral Research·Simon-Djamel ThibervilleXavier de Lamballerie
Mar 19, 2014·The American Journal of Tropical Medicine and Hygiene·Kara E RudolphDerek A T Cummings
Oct 25, 2014·PloS One·Anuradha VenugopalanArvind Chopra
Nov 5, 2014·Frontiers in Immunology·Gestur VidarssonTheo Rispens
Feb 19, 2016·Journal of Virology·Suzanne P M WeltenRamon Arens
Feb 26, 2016·The Indian Journal of Medical Research·Deepti ParasharV Ravindra Babu
Nov 1, 2016·Journal of Virology·Anmol ChandeleKaja Murali-Krishna
Nov 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M Fox, Michael S Diamond
Jan 27, 2017·PLoS Neglected Tropical Diseases·Vijayalakshmi ReddyRavi Vasanthapuram
Feb 10, 2017·PloS One·Chong-Long ChuaYoke-Fun Chan
Mar 2, 2017·The Journal of Clinical Investigation·Laurie A Silva, Terence S Dermody
Apr 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaspreet JainSujatha Sunil
Jan 1, 2014·WHO South-East Asia Journal of Public Health·Dayaraj Cecilia
Sep 15, 2017·Viral Immunology·Sarika AmdekarKalichamy Alagarasu
Oct 11, 2017·Journal of Infection and Public Health·Anju DinkarGopal Nath
Feb 2, 2018·Current Opinion in Rheumatology·Ravi B SutariaRobert T Schoen
Oct 27, 2018·Frontiers in Cellular and Infection Microbiology·Ithallo S B TanabeÊnio J Bassi
Jan 19, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sivaram GunisettyAnmol Chandele
Nov 2, 2019·Infectious Disease Clinics of North America·Francesco VairoAlimuddin Zumla

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.