Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

Infection and Immunity
T C UsheT F McElwain

Abstract

Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.

References

Jan 1, 1977·Advances in Experimental Medicine and Biology·L L Callow
Jun 16, 1992·Annals of the New York Academy of Sciences·J V FigueroaT F McElwain
Jul 1, 1992·Molecular and Biochemical Parasitology·V S MishraE B Stephens
May 1, 1991·Journal of Clinical Microbiology·J V Figueroa, G M Buening
Feb 1, 1987·International Journal for Parasitology·A D Irvin
Nov 1, 1993·Experimental Parasitology·R Z MachadoG H Palmer

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Citations

Jan 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B J RuefW C Brown
Jul 23, 1996·Annals of the New York Academy of Sciences·W C BrownG H Palmer
Jun 1, 1996·Infection and Immunity·S D RodríguezW C Brown
Jul 25, 2000·Clinical Microbiology Reviews·M J HomerD H Persing

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