PMID: 25749042Mar 10, 2015Paper

Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer

Oncotarget
Xavier Etienne KellerMaurizio Provenzano

Abstract

Infectious agents, including the BK polyomavirus (BKPyV), have been proposed as important inflammatory pathogens in prostate cancer. Here, we evaluated whether the preoperative antibody response to BKPyV large T antigen (LTag) and viral capsid protein 1 (VP1) was associated with the risk of biochemical recurrence in 226 patients undergoing radical prostatectomy for primary prostate cancer. Essentially, the multivariate Cox regression analysis revealed that preoperative seropositivity to BKPyV LTag significantly reduced the risk of biochemical recurrence, independently of established predictors of biochemical recurrence such as tumor stage, Gleason score and surgical margin status. The predictive accuracy of the regression model was denotatively increased by the inclusion of the BKPyV LTag serostatus. In contrast, the VP1 serostatus was of no prognostic value. Finally, the BKPyV LTag serostatus was associated with a peculiar cytokine gene expression profile upon assessment of the cellular immune response elicited by LTag. Taken together, our findings suggest that the BKPyV LTag serology may serve as a prognostic factor in prostate cancer. If validated in additional studies, this biomarker may allow for better treatment decisions...Continue Reading

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Dec 25, 2015·Journal of Translational Medicine·Mauro Tognon, Maurizio Provenzano
Aug 27, 2015·Reviews in Medical Virology·Etienne Xavier KellerMaurizio Provenzano

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