Antibody response to the 60-kDa chlamydial heat-shock protein is associated with scarring trachoma

The Journal of Infectious Diseases
R W PeelingD C Mabey

Abstract

To determine if serum antibody response to the 60-kDa chlamydial heat-shock protein (Chsp60) was associated with scarring trachoma, responses to Chlamydia trachomatis and to Chsp60 from 148 Gambian subjects with trachomatous scarring and from 148 controls without clinical evidence of disease from trachoma-endemic communities were characterized. Chsp60 response was found in 32% of cases and 16% of controls (P < .001). Although C. trachomatis titer was also higher in cases than controls, the prevalence of Chsp60 response between the 2 groups remained significantly different after stratifying for C. trachomatis titer (weighted odds ratio [OR] = 2.1, P = .02). Chsp60 response and C. trachomatis serovar A titer of > or =128 were independently associated with scarring trachoma. The presence of HLA class II allele DRB1*0701 was positively correlated with Chsp60 response (OR = 2.6, P = .02), and DQB1*0301 and DQB1*0501 were negatively associated (OR = 0.42, P < .001; OR = 0.55, P = .46, respectively).

Citations

Jan 16, 2003·Trends in Microbiology·Richard S Stephens
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David L Hahn, Rosanna W Peeling
Oct 29, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D L Hahn
Mar 17, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D L HahnP Saikku
Nov 17, 2006·Nature Reviews. Microbiology·Rosanna W PeelingEdward W Hook
Nov 18, 2006·Nature Reviews. Microbiology·Rosanna W PeelingEdward W Hook
Mar 29, 2000·Scandinavian Journal of Immunology·C SvanholmM E Rottenberg
Jul 6, 2001·Scandinavian Journal of Immunology·A KinnunenH M Surcel
May 20, 2004·Journal of Bacteriology·Adam C Wilson, Ming Tan
Feb 14, 2004·Journal of Immune Based Therapies and Vaccines·Kei Numazaki
Mar 5, 2013·PLoS Neglected Tropical Diseases·Victor H HuMatthew J Burton
Nov 13, 2002·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·P KopecekE Weigl
Jul 30, 2003·Lancet·David C W MabeyAllen Foster
Sep 29, 2009·European Journal of Internal Medicine·Georgios S PapaetisDora Orphanidou
Jun 10, 2008·Lancet·Heathcote R WrightHugh R Taylor
Jun 29, 2004·Progress in Retinal and Eye Research·Sheila K West
Oct 2, 2015·Mediators of Inflammation·Tamsyn DerrickMartin J Holland
Jul 22, 2014·Lancet·Hugh R TaylorHeathcote Wright
May 7, 2009·FEMS Microbiology Reviews·Peter A Lund
Mar 13, 2014·Vaccine·David C W MabeyMartin J Holland
Jan 6, 2011·FEMS Immunology and Medical Microbiology·Brigida Rusconi, Gilbert Greub
Apr 19, 2003·Genome Biology·Hans AckermanDominic P Kwiatkowski
Oct 13, 2006·Current Opinion in Infectious Diseases·S Ghaem-Maghami, D J Lewis
Oct 13, 2006·Current Opinion in Infectious Diseases·X Yang, R C Brunham
Feb 28, 2003·Epidemiology·Kassandra L MungerAlberto Ascherio
Jul 27, 2001·Ophthalmic Epidemiology·S K WestM C Lynch
Mar 5, 2002·Scandinavian Journal of Infectious Diseases·Hertzen Leena VonMirja Puolakkainen
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anil K ChaturvediEric A Engels
Sep 13, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Alyce AlvenRachel L Redfern

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.