PMID: 2500956Apr 1, 1989Paper

Antibody response to the viral negative factor (nef) in HIV-1 infection: a correlate of levels of HIV-1 expression

AIDS
P ReissJ Goudsmit

Abstract

Antibody responses against the nef gene product of HIV-1 were determined in sequential sera from a longitudinally studied cohort of 194 initially asymptomatic HIV-1-seropositive individuals and 72 individuals who seroconverted for antibodies to HIV-1 structural proteins (gag/env). In the majority of men, nef-specific antibodies, once detected, persisted (67.6%). In some men, nef-specific antibodies were only transiently (6.8%), or intermittently (5.3%), detectable. No nef-specific antibodies were found in the remaining men (20.3%). Nef-specific antibodies were elicited early in infection, but rarely (2/72 men) prior to seroconversion for antibodies to HIV-1 structural proteins. An absent, transient, or intermittent nef-specific antibody response was significantly associated with the absence or disappearance of antibodies to HIV-1 core proteins, with (re)appearance and persistence of HIV-1 core antigen and with the presence of low CD4+ cell numbers, i.e. profiles previously shown to be predictive of rapid disease progression. Although more cases of AIDS and AIDS-related disease (21/86 versus 28/180) occurred in the nef-specific antibody-negative group than in the nef-specific antibody-positive group, this difference did not reac...Continue Reading

Citations

Aug 1, 1990·Journal of Medical Virology·S O'SheaJ E Banatvala
Sep 1, 1991·Journal of Medical Virology·S O'SheaJ E Banatvala
Jan 1, 1993·Archives of Virology·H SiakkouG Jung
Jan 1, 1991·Archives of Virology·N KienzleN Müller-Lantzsch
Jan 1, 1992·Research in Virology·F Kirchhoff, G Hunsmann
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E BriginoN K Day
Aug 13, 1999·AIDS Research and Human Retroviruses·T Yamada, A Iwamoto
Sep 1, 1990·AIDS Research and Human Retroviruses·R Cheingsong-PopovJ Weber
Feb 25, 2014·Journal of the International AIDS Society·Guillermo CorróLuisa Sen
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Jan 1, 1991·Clinics in Dermatology·F de Wolf, J M Lange
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Jan 1, 1994·Clinical Microbiology Reviews·C M Tsoukas, N F Bernard
Jan 5, 2021·Protein and Peptide Letters·Alireza MilaniAzam Bolhassani

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