Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Tahmina ShirinFirdausi Qadri


Studies on serologic responses following COVID-19 have been published primarily in individuals who are moderately or severely symptomatic, but there are few data from individuals who are mildly symptomatic or asymptomatic. We measured IgG, IgM, and IgA to the receptor-binding domain of SARS-CoV-2 by ELISA in mildly symptomatic (n = 108) and asymptomatic (n = 63) on days 1, 7, 14, and 30 following RT-PCR confirmation in Bangladesh, and compared with pre-pandemic samples, including healthy controls (n = 73) and individuals infected with other viruses (n = 79). Mildly symptomatic individuals developed IgM and IgA responses by day 14 in 72% and 83% of individuals, respectively, while 95% of individuals developed IgG response, and rose to 100% by day 30. In contrast, individuals infected with SARS-CoV-2 but who remained asymptomatic developed antibody responses significantly less frequently, with only 20% positive for IgA and 22% positive for IgM by day 14, and 45% positive for IgG by day 30 after infection. These results confirm immune responses are generated following COVID-19 who develop a mildly symptomatic illness. However, those with the asymptomatic infection do not respond or have lower antibody levels. These results will im...Continue Reading


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Methods Mentioned

enzyme-linked immunosorbent assay
size exclusion chromatography

Software Mentioned

GraphPad Prism

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