Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

Parasite Immunology
Craig T KyngdonM W Lightowlers

Abstract

Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.

References

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Citations

Feb 24, 2010·Parasitology Research·Aijiang GuoXuenong Luo
Jul 9, 2011·Bioinformation·Mirko ZimicPatricia Sheen
Sep 14, 2007·Molecular and Biochemical Parasitology·Holger MaytaUNKNOWN Cysticercosis Working Group in Peru
Jan 10, 2008·Trends in Parasitology·Karen L HaagFrancisco J Ayala
Nov 26, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andreas HofmannMalcolm K Jones
Nov 4, 2009·International Journal for Parasitology·Abdul JabbarMarshall W Lightowlers
Feb 9, 2010·International Journal for Parasitology·Emmanuel AssanaMarshall W Lightowlers
Jul 29, 2015·The American Journal of Tropical Medicine and Hygiene·Bradford W LeeBobby S Korn
Mar 1, 2013·The Journal of Parasitology·Edda SciuttoCarlos Larralde
Aug 3, 2010·Applied and Environmental Microbiology·Cara J ChrismanArturo Casadevall

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