PMID: 9194209Jan 1, 1997Paper

Antibody responses to gut bacteria in ankylosing spondylitis, rheumatoid arthritis, Crohn's disease and ulcerative colitis

Rheumatology International
H TiwanaAlan Ebringer

Abstract

Specific immunoreactive anti-Klebsiella antibodies are found in patients with ankylosing spondylitis (AS), a significant proportion of whom have occult inflammatory bowel disease. Molecular mimicry between Klebsiella or other bacterial antigens and HLA-B27 has been suggested in the pathogenesis of AS. The specificity of increased immunoreactivity against Klebsiella remains to be assessed against the abundant anaerobic bacterial flora, present either in healthy controls or in patients with ulcerative colitis (UC) and Crohn's disease (CD). Total immunoglobulin (Ig; IgG, IgA, IgM) immunoreactivity was measured by ELISA against Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli and ten anaerobic isolates of the predominant normal bowel flora in 35 patients with active AS, 60 patients with inflammatory bowel disease (30 CD, 30 UC), 60 patients with active rheumatoid arthritis (RA) and 60 healthy controls. Ig immunoreactivity to K. pneumoniae was significantly elevated in AS (P < 0.001), CD (P < 0.001) and UC (P < 0.001) patients compared with RA patients and healthy controls. Furthermore, Ig immunoreactivity to P. mirabilis was significantly elevated only in RA patients, compared with the other inflammatory groups (P < 0.001...Continue Reading

Citations

Aug 31, 2006·Clinical Rheumatology·Alan EbringerClyde Wilson
Dec 23, 2006·Clinical Rheumatology·Taha Rashid, Alan Ebringer
Jan 9, 2007·Clinical Rheumatology·Taha Rashid, Alan Ebringer
Aug 8, 2002·Journal of Gastroenterology and Hepatology·Toshifumi OhkusaIsao Okayasu
Mar 14, 2002·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·John McDougallMary McDougall
Sep 14, 2001·Current Opinion in Rheumatology·K L Hyrich, R D Inman
Jun 5, 2007·Current Opinion in Gastroenterology·Jan WehkampEduard F Stange
Jan 10, 2002·Clinical Microbiology Reviews·Barbara A HendricksonJudy H Cho
Sep 22, 2006·Journal of Clinical Microbiology·Uri GophnaSander J O Veldhuyzen van Zanten
Jun 20, 2013·Clinical & Developmental Immunology·Taha RashidAlan Ebringer
Nov 14, 2013·International Journal of Rheumatology·Taha RashidClyde Wilson
Dec 3, 2016·Zeitschrift für Rheumatologie·Y KangJ Su
Jan 28, 2003·Rheumatology International·Yusuf AydinAyşen Akinci
Apr 9, 2009·European Journal of Gastroenterology & Hepatology·Taha RashidMark Fielder
Mar 3, 2010·Immunological Reviews·Ann Duskin, Robert A Eisenberg
Dec 2, 2009·Journal of the Chinese Medical Association : JCMA·Yi-Chun LinHsiao-Yi Lin
Dec 17, 2008·Scandinavian Journal of Gastroenterology·Hans HildebrandScott M Montgomery
Mar 30, 2011·Journal of Chemical Ecology·Zsofia SzendreiCesar Rodriguez-Saona
Mar 15, 2003·Scandinavian Journal of Rheumatology·Alan EbringerClyde Wilson
Sep 26, 2013·Acta Microbiologica Et Immunologica Hungarica·Vesna Kovačević-JovanovićMirjana Dimitrijević
Jan 5, 2002·Journal of Food Protection·J E Harris, A M Lammerding
Apr 9, 2018·Rheumatology International·Biljana Radovanović-DinićSaša Grgov
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alan Ebringer, Taha Rashid
Feb 12, 2021·Seminars in Immunopathology·Katharine Lu YangSergei B Koralov

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