Nov 30, 2019

Antibody responses to immunization require sensory neurons

bioRxiv
Aisling TynanKevin J. Tracey

Abstract

Mammals store memories in the nervous and immune systems. Sensory neurons have been implicated in enhancing neurological memory, but whether neurons participate during immunity to novel antigens is unknown. Here, mice rendered deficient in transient receptor potential vanilloid 1 (TRPV1)-expressing sensory neurons, termed nociceptors, fail to develop competent antibody responses to KLH and hapten-NP. Moreover, selective optogenetic stimulation of TRPV1 neurons during immunization significantly enhanced antibody responses to antigens. Thus, TRPV1 nociceptors mediate antibody responses to novel antigen, and stimulating TRPV1 nociceptors enhances antibody responses during immunization. This is the first genetic and selective functional evidence that nociceptors are required during immunization to produce antigen-specific antibodies.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Keyhole-limpet hemocyanin
Neurons
Antigens
Vanilloid
Afferent Neuron
Optogenetics
TRPV1
Immunization
Nociceptors
Specific antibody

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Claire A SandManasi Nandi
International Journal of Clinical Pharmacology and Therapeutics
Robert D MurdochDeepen Patel
© 2020 Meta ULC. All rights reserved