Antibody responses to prostate-associated antigens in patients with prostatitis and prostate cancer.

The Prostate
Brett B MaricqueDouglas G McNeel

Abstract

An important focus of tumor immunotherapy has been the identification of appropriate antigenic targets. Serum-based screening approaches have led to the discovery of hundreds of tumor-associated antigens recognized by IgG. Our efforts to identify immunologically recognized proteins in prostate cancer have yielded a multitude of antigens; however, prioritizing these antigens as targets for evaluation in immunotherapies has been challenging. In this report, we set out to determine whether the evaluation of multiple antigenic targets would allow the identification of a subset of antigens that are common immunologic targets in patients with prostate cancer. Using a phage immunoblot approach, we evaluated IgG responses in patients with prostate cancer (n = 126), patients with chronic prostatitis (n = 45), and men without prostate disease (n = 53). We found that patients with prostate cancer or prostatitis have IgG specific for multiple common antigens. A subset of 23 proteins was identified to which IgG were detected in 38% of patients with prostate cancer and 33% patients with prostatitis versus 6% of controls (P < 0.001 and P = 0.003, respectively). Responses to multiple members were not higher in patients with advanced disease, s...Continue Reading

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Citations

Jan 5, 2011·Journal of Biomedicine & Biotechnology·Heath A SmithDouglas G McNeel
Mar 25, 2014·Clinical and Experimental Immunology·N E AnnelsH Pandha
Jun 20, 2020·Proteomics. Clinical Applications·Chen ChenHans Neubauer
Dec 19, 2020·Journal for Immunotherapy of Cancer·Hemanth K PotluriDouglas G McNeel

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