PMID: 9420231Jan 7, 1998Paper

Antibody-secreting cell responses and protective immunity assessed in gnotobiotic pigs inoculated orally or intramuscularly with inactivated human rotavirus

Journal of Virology
L YuanL J Saif

Abstract

Newborn gnotobiotic pigs were inoculated twice perorally (p.o.) (group 1) or intramuscularly (i.m.) (group 2) or three times i.m. (group 3) with inactivated Wa strain human rotavirus and challenged with virulent Wa human rotavirus 20 to 24 days later. To assess correlates of protection, antibody-secreting cells (ASC) were enumerated in intestinal and systemic lymphoid tissues from pigs in each group at selected postinoculation days (PID) or postchallenge days. Few virus-specific ASC were detected in any tissues of group 1 pigs prior to challenge. By comparison, groups 2 and 3 had significantly greater numbers of virus-specific immunoglobulin M (IgM) ASC in intestinal and splenic tissues at PID 8 and significantly greater numbers of virus-specific IgG ASC and IgG memory B cells in spleen and blood at challenge. However, as for group 1, few virus-specific IgA ASC or IgA memory B cells were detected in any tissues of group 2 and 3 pigs. Neither p.o. nor i.m. inoculation conferred significant protection against virulent Wa rotavirus challenge (0 to 6% protection rate), and all groups showed significant anamnestic virus-specific IgG and IgA ASC responses. Hence, high numbers of IgG ASC or memory IgG ASC in the systemic lymphoid tiss...Continue Reading

Citations

Aug 12, 1999·Clinical and Experimental Immunology·K H ThielkeH J Rothkötter
Feb 13, 2008·Expert Reviews in Molecular Medicine·Richard L Ward
Aug 31, 2006·Physiological Genomics·Cheryl M T DvorakMichael P Murtaugh
Sep 3, 2010·Clinical and Vaccine Immunology : CVI·Sangun LeeJohn E Herrmann
Feb 4, 2011·The Journal of Infectious Diseases·Ulrich Desselberger, Hans-Iko Huppertz
Nov 12, 2014·Annual Review of Animal Biosciences·Kuldeep S ChatthaLinda J Saif
Dec 9, 2014·Acta Crystallographica. Section F, Structural Biology Communications·Yusheng TanHaitao Yang
Sep 10, 2016·World Journal of Gastroenterology : WJG·Jin-Tao LiYu-Zhang Wu
Feb 15, 2005·Journal of Virology·Lisa LindesmithRalph S Baric
Jan 24, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sukumar KandasamyLinda J Saif

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